血清降钙素原和血清前白蛋白检测在呼吸道感染性疾病中的应用

目的：探讨血清降钙素原（PCT）和血清前清蛋白（PA）检测在呼吸道感染性疾病诊断中的临床价值。方法选取90例经呼吸内科确诊的细菌感染患者为观察组，另选48例健康体检者为对照组。PCT和PA检测分别采用免疫发光法和比色法，测定两组血清水平，并进行统计学分析。结果观察组患者PCT水平显著高于对照组（χ2=7.512，P=0.0046），而PA水平则低于对照组（χ2=7.126，P=0.0058）；观察组患者以上两项指标阳性率显著高于对照组（χ2=7.628，P=0.0047）。治疗1周后，观察组PCT水平显著降低，而PA水平显著升高，治疗前后差异具有统计学意义（χ2=3.629，P=0.034）。结论血清PCT和PA测定可作为呼吸道感染性疾病诊断和鉴别诊断的常规指标，对指导抗菌药物的合理使用，病情评估和疗效判断均具有重要的指导意义。

Clinical application of serum procalcitonin and prealbumin in the diagnosis of respiratory tract infections

Objective To investigate the diagnosis siginificance of serum procalcitonin （PCT） and prealbumin （PA） in patients with bacterial respiratory tract infections. Methods Total of 90 patients with bacterial infection from department of respiratory medicine were enrolled as observation group and 48 cases of healthy as control group. The serum levels of PCT and PA of the two groups were detected by immuonluminescent assay and electrochemical method, respectively. Results The serum level of PCT in observation group was siginificantly higher than that in B group （χ2= 7.512, P= 0.0046）, but with siginiifcantly lower level of PA （χ2=7.126, P=0.0058） and siginiifcantly higher positive rate of serum PCT and PA （χ2=7.62, P=0.0047）. One week after treatment, the observation group had signiifcant reduction of PCT, and a signiifcant increase of PA, with signiifcant difference before and after treatment （χ2=3.62, P=0.034）. Conclusions Serum levels of PCT and PA could be used as speciifc indicators of bacterial respiratory tract infections and with guilding siginiifcance for clinical diagnosis and treatment.