6种药物对部队进入海拔5200m急性高原反应预防效果的对比观察

目的 :筛选预防急性高原反应的药物。方法 :进驻海拔 5 2 0 0m哨卡的某部 118名士兵随机分为 6组。将复方红景天、银杏叶片、酪氨酸、复方党参、乙酰唑胺、异叶青兰组列为A、B、C、D、E、F组 ,每组 18～ 2 0人。于进入高原前 4天开始 ,每日早晚各服药 1次 ,到哨卡第 3天停药 ,连服 12d。部队进驻哨卡第 1～ 7天 ,以军用卫生标准GJB10 98- 91《急性高原反应的诊断和处理原则》随访记录受试者每天的急性高原反应症状 ,然后分度评分。分值高者 ,高原反应症状重。结果 :部队进入哨卡第 1天 ,A组症状评分较C、D、E、F组低 ,C组较A、D、E、F组高 (P <0 .0 1或P <0 .0 5 )。第 3天 ,除F组外 ,C组均高于其它 4组 ,B和E组较D组低 (P <0 .0 5或P <0 .0 1)。第 5天 ,A和B组较C组低 ,A组较D组低 (P <0 .0 5或P <0 .0 1)。第 7天 ,B组较A、C和D组低 ,F组较A、C和B组高 (P <0 .0 5或P <0 .0 1)。结论 :银杏叶片预防急性高原反应效果最好 ,乙酰唑胺和复方红景天次之 ,复方党参较异叶青兰好 ,酪氨酸最差

Role of six different medicines in the symptomatic scores of benign form of acute mountain sickness

Objective: To choose the medicine that has a good effect on preventing the acute mountain sickness.Methods:In a randomized study,118 soldiers were divided into 6 groups (rhodiola,gingkgo biloba,tyrosine,compound dangshen,acetazolamide, and isoleaf orchid group), each had 18-20 person. Each soldier took his medicine twice a day for 12 days (4 days before driving from altitude 1 400 m to 5 200 m,and stopped taking medicine at the third day after arrived).The symptomatic scores of acute mountain sickness were recorded for 7 days since they arrived 5 200 m altitude.Results:The first day,rhodiola group had a lower score and tyrosine group was higher than others'( P <0.01 or P <0.05); The third day,gingkgo biloba and acetazolamide group were lower than compound dangshen group( P <0.05 or P< 0.01); The fifth day,rhodiola and gignkgo biloba group were lower than tyrosine group, gingkgo biloba group was lower than compound dangshen group( P <0.05 or P <0.01);The seventh day,gingkgo biloba group was lower than rhodiola,tyronsine and compound dangshen group,isoleaf group was higher than rhodiola,tyrosine and gingkgo biloba group( P <0.01 or P <0.05).Conclusion:Our study shows that the efficacy order of the six drugs is gingkgo biloba,acetazolamide,rhodiola,compound dangshen,isoleaf orchid and tyrosine.