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| 食管鳞癌发生过程中nm23-H_1蛋白的表达 | |
| 引用本文： | 赵高峰,张云汉,高冬玲,张三申,赵胡方,赵志忠. 食管鳞癌发生过程中nm23-H_1蛋白的表达[J]. 郑州大学学报(医学版), 1997, 0(3) |
| 作者姓名： | 赵高峰 张云汉 高冬玲 张三申 赵胡方 赵志忠 |
| 作者单位： | 中国协和医科大学基础所病理科，河南医科大学第一附属医院病理科，安阳市肿瘤医院病理科，安阳地区人民医院病理科 |
| 基金项目： | 国家“八五”科技攻关项目,河南省重大科技攻关项目 |
| 摘 要： | 应用免疫组化ＬＳＡＢ技术对６３例食管鳞癌及癌旁粘膜进行ｎｍ２３Ｈ１蛋白表达检测。结果：阳性表达产物主要位于细胞浆；随着癌旁粘膜病变程度的加重，ｎｍ２３Ｈ１表达呈下降趋势，且轻度病变与重度不典型增生，原位癌及鳞状细胞癌之间差异有显著性；食管鳞癌分化越差，ｎｍ２３Ｈ１表达越低（Ｐ＜０．００５）；非转移组ｎｍ２３Ｈ１蛋白表达率明显高于转移组（Ｐ＜０．０５）。提示：ｎｍ２３Ｈ１在人食管鳞癌发生发展过程中起重要的抑制作用。 |
| 关 键 词： | 食管肿瘤；鳞癌；nm23-H_1；免疫组化；转移 |
Expression of nm23 H 1 during the carcinogenesis and development of human esophageal squamous cell carcinoma |
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| Zhao Gaofeng ),Zhang Yunhan ),Gao Dongling ),Zhang Sansen ),Zhao Hufang ),Zhao Zhizhong ) ). Expression of nm23 H 1 during the carcinogenesis and development of human esophageal squamous cell carcinoma[J]. Journal of Zhengzhou University: Med Sci, 1997, 0(3) | |
| Authors: | Zhao Gaofeng ) Zhang Yunhan ) Gao Dongling ) Zhang Sansen ) Zhao Hufang ) Zhao Zhizhong ) ) |
| Affiliation: | Zhao Gaofeng 1),Zhang Yunhan 2),Gao Dongling 2),Zhang Sansen 3),Zhao Hufang 4),Zhao Zhizhong 4) 1)Department of Pathology,Institute of Basic Medical Science,Beijing Union Medical University,Beiing 100005 2) |
| Abstract: | With immunohistochemical LSAB technique,we examined the expression of nm23 H 1 in 63 cases of esphageal squamous cell carcinoma and their pericancerous mucosa.The positive cells were mainly seen in cytoplasmic staining.With the increase of severity of lesions in pericancer mucosa,nm23 H 1 expression decreased accordingly.The carcinoma tissue had a 26.98% expression rate.The inverse correlation could be seen between nm23 H 1 expression and the carcinoma differentiative degrees.We also observed the significant inverse correlation between the nm23 H 1 expression and the lymphic metdstatic rate.The results indicated that nm23 H 1 might play an important role in the carcinogenesis and development of human esophageal squamous cell carcinoma. |
| Keywords: | exophageal squamous cell carcinoma nm23 H 1 immunohistochemistry metastasis |
| 本文献已被 CNKI 等数据库收录！ | |