多药耐药相关蛋白及肺耐药蛋白在人直肠癌组织中的表达及临床 …

目的 检测多药耐药相关蛋白（ＭＲＰ）及肺耐药蛋白（ＬＲＰ）在人直肠癌组织中的表达,探讨其与临床分期、分化程度及预后的关系。方法 采用免疫组织化学技术法检测５７例人直肠癌组织中ＭＲＰ及ＬＲＰ的表达。结果 ５７例人直肠癌组织中可检测到ＭＲＰ表达者２８例,占４９．１％;ＬＲＰ表达者２４例,占４２．１％;二者同时表达者１０例,占１７．５％;有ＭＲＰ或ＬＲＰ表达者４２例,占７３．７％;两蛋白表达阳性率与肿瘤

Expression of multidrug resistance-associated protein (MRP) and lung resistance protein (LRP) in human rectal carcinomas and its clinical significance]

OBJECTIVE: To investigate the expression and clinical significance of multidrug resistance-associated protein(MRP) and lung resistance protein(LRP) in rectal carcinoma. METHODS: Fiftyseven paraffin embeded primary rectal carcinoma specimens were examined by immunohistochemical staining. RESULTS: Of the 57 tumour specimens examined, 28(49.1%) and 24(42.1%) were positively immunostaned for MRP and LRP, respectively. Co-expression of the two proteins was observed in 10(17.5%) specimens. Positive immunostaning of either of the two proteins was not correlated with cell differentiation and Dukes stage (P > 0.05). Patients with MRP-positive tumours had shorter survival than MRP-negative patients (P < 0.05). No such correlation was found for LRP expression, nor was found between MRP and LRP expression. CONCLUSION: Positive MRP expression in rectal carcinoma appears to be an independant factor of prognostic significance. To examine its expression may help guide rational comprehensive therapy of rectal carcinoma.