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NR4A2 genetic variation in sporadic Parkinson's disease: a genewide approach. |
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| Authors: | Daniel G Healy Patrick M Abou-Sleiman Kourosh R Ahmadi Sonia Gandhi Miratul M Muqit Kailash P Bhatia Niall P Quinn Andrew J Lees Janice L Holton Tamas Revesz Nicholas W Wood |
| Affiliation: | Department of Molecular Neuroscience, Institute of Neurology, London, United Kingdom. d.healy@ion.ucl.ac.uk |
| Abstract: | The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype-tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population. |
| Keywords: | NR4A2 Parkinson's disease genewide study haplotype tagging |