三联疗法根除幽门螺杆菌的临床观察

目的观察奥美拉唑、阿莫西林及不同剂量呋喃唑酮三联疗法根除幽门螺杆菌（Hp）的疗效和安全性。方法120例Hp阳性的消化性溃疡患者随机分为4组，每组各30例。对照组采用奥美拉唑（20mg，Bid）＋阿莫西林（1g，Bid）＋甲硝唑（400mg，Bid）治疗，疗程1wk；A、B、C三治疗组分别采用3种不同剂量呋喃唑酮（100mg、200mg、300mg，Bid）＋奥美拉唑（20mg，Bid）＋阿莫西林（1g，Bid）治疗，疗程1wk。观察、记录治疗过程中发生的各种不良反应，疗程结束4wk后复查胃镜和Hp检测。结果对照组和A、B、C三治疗组Hp根除率和溃疡愈合率分别为：59．3％、58．6％、85．7％、84．6％和63．0％、65．5％、89．3％、88．5％。A组Hp根除率和溃疡愈合率与对照组无差异（P〉0．05）；B、C组Hp根除率和溃疡愈合率明显高于对照组和A组（P〈0．05）；B、C两组间Hp根除率和溃疡愈合率无显著性差异（P〉0．05）。各组间不良反应发生率无显著性差异（P〉0．05）。结论两倍标准剂量呋喃唑酮三联疗法根除幽门螺杆菌疗效好、不良反应少，可替代甲硝唑作为Hp根除治疗的一线用药。

Clinical observation of effect of combined use of omeprazole,amoxicillin and furazolidone on eradication of Helicobacter pylori

Objective To observe the efficacy and safety of combined use of omeprazole , amoxicillin and furazolidone in eradication of Helicobacter pylori （H. pylori）. Methods There 120 patients with peptic ulcer and positive H. pylori were randomly allocated into four groups each consisted of 30 patients. The patients in control group received omeprazole 20mg ＋ amoxiciUin 1 g ＋ metronidazole 400 mg, twice daily each, for one week; The patients in treatment group A,B and C received different doses of furazolidone （100,200,300mg） respectively ＋ omeprazole 20mg ＋ amoxiciUin lg, twice daily for one week. Side effects were observed and recorded during the treatment; endoscopy was.performed and H. pylori was detected repeatedly four weeks after the end of treatment. Results The eradication rates of H. pylori were 59.3% ,58.6% ,85.7%, 84.6% and the healing rates of peptic ulcer were 63.0% ,65.5% ,89.3% ,88.5% in control group and treatment groupA - C respectively. There were no difference in H. pylori eradication rates and healing rates of peptic ulcer between control group and groupA （P 〉 0.05 ） ; The eradication rates of H. pylori and healing rates of peptic ulcer in group B and C were obviously higher than those in control group and groupA （P 〈 0.05 ）, but there were no difference in eradication rates ofH. pylori and healing rates of peptic ulcer between group B and group C （P 〉 0.05 ） ; There were no difference in occurance rates of side effects among these four groups （P 〉 0.05 ）, Conclusion The effect of combined use of omeprazole, amoxiciUin and twice dose of furazolidone is highly effective in eradication of H. pylori and with light side effect, and It may replace metronidazole and be as the the first line drug in eradication of H. pylori.