降钙素原在儿童支气管肺炎病原诊断中的临床价值

目的评估降钙素原(PCT)在鉴别支气管肺炎细菌和病毒感染中的价值。方法选取2010年10月至2011年12月在深圳市儿童医院重症监护室住院的肺炎患儿50例,其中细菌性肺炎组27例,病毒性肺炎组23例,均在入选后行PCT测定和C反应蛋白(CRP)、痰培养等检测。结果细菌性肺炎组和病毒性肺炎组中的PCT在0.5～2μg/L、3～10μg/L和>10μg/L时的阳性结果显示,细菌性肺炎组的PCT阳性率明显高于病毒性肺炎组,分别为70.37%和21.74%,比较差异有统计学意义(χ2=48.07,P=0.000),同时细菌性肺炎组中PCT值的分布又明显高于病毒性肺炎组,差异具有统计学意义(Z=26.01,P=0.000),PCT在介于0.5μg/L和2.0μg/L之间时,在细菌性肺炎组和病毒性肺炎组中表达的比例分别为44.4%和8.70%,差异具有统计学意义(χ2=7.87,P=0.005),而CRP值在8～30 mg/L和≥30 mg/L两层面中,细菌性肺炎组和病毒性肺炎组之间无明显差异。结论PCT检测有助于区分肺炎的细菌和病毒感染,优于CRP。

Clinical Study on Procalcitonin in the Diagnosis of Pneumonia Pathogens in Children

Objective To evaluate diagnostic value of procalcitonin(PCT) in identification of bronchial pneumonia bacterial and viral infections.Methods 50 children in Shenzhen Children′s Hospital Intensive Care Unit from October 2010 to December 2011 were enrolled into this study,27cases in the bacterial pneumonia group,23 cases in the viral pneumonia group.All cases were measured PCT,C reactive protein and took sputum culture.Results PCT of 0.5-2,2-10 and>10μg/L in bacterial pneumonia group and viral pneumonia group showed that the PCT positive rate in bacterial pneumonia group was obviously higher than virus pneumonia group(70.37% VS 21.74%,χ2=48.07,P=0.000);the PCT value in bacterial pneumonia group was higher than virus pneumonia group too(Z=26.01,P=0.000),PCT between 0.5μg/L and 2.0μg/L,the expression rate of bacterial pneumonia group and virus pneumonia group was 44.4% and 8.70% respectively,There were significant differences(χ2=7.87,P= 0.005).While the CRP was in the 8-30 mg/L and >30 mg/L group,there were no obvious differences between the two groups.Conclusion PCT can help to distinguish the pneumonia with bacterial infections from viral infections,which is superior to C-reactive protein.