吸入麻醉药与术后认知功能障碍关系的研究进展

术后认知功能障碍(POCD)是一种常见的术后并发症,在老年人中发病率较高,多数为一过性的,少数严重者可影响术后生活质量。近年研究发现,麻醉和手术是POCD发生的重要危险因素,尤其是吸入麻醉药可引起患者的认知功能下降,但具体机制目前仍未完全阐明,可能与β淀粉样蛋白的积聚、神经炎症、神经元内钙失衡、突触可塑性下降以及一氧化氮的改变等有关。

Research Progress of Relationship between Inhalational Anesthetics and Postoperative Cognitive Dysfunction

Postoperative cognitive dysfunction(POCD) is a common complication following major surgery.It is frequently seen in old age group and usually its effect is short-term,but in some cases,it can severely affect their life quality.Studies in recent years have found that anesthesia and surgery are important risk factors for the occurrence of POCD.In particular,inhalational anesthetics may cause the cognitive decline of the patients,though the concrete mechanism is still unclear,and it may be caused by Amyloid β accumulation,neuro-inflammation,neuronal calcium homeostasis,synaptic plasticity dysfunction and NO change following anesthesia.