川崎病发病机制研究进展

川崎病是一种急性全身性中小血管炎性综合征,主要累及冠状动脉,可以引起冠状动脉扩张、冠状动脉狭窄甚至心肌梗死,是儿童后天性心脏病的主要原因。目前研究显示,川崎病发病主要与以下因素有关:微生物毒素类超抗原介导作用,某些微生物产物对T细胞有超强激活能力;免疫系统异常激活,T细胞和B细胞异常激活产生大量的细胞因子、炎性介质引起血管内皮损伤;种族遗传因素等。

Research Development of Kawasaki Disease Pathogenesis

Kawasaki disease is an acute systemic small vasculitis syndrome,mainly involving coronary artery,which can cause dilatation of coronary artery,coronary artery stenosis and myocardial infarction,and is the main reason for acquired heart disease in children.The present study shows Kawasaki disease is mainly related to the following factors: microbial toxin superantigens mediating effects,some microbial products super activating ability on T cells,abnormal immune system activation,abnormal activation of T cells and B cells producing large amounts of cytokines and inflammatory matter causing vascular endothelial injury,racial genetic factors and so on.