| 肝硬化大鼠胃肠运动及胃动素受体表达的实验研究 |
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| 引用本文： | 殷积彬,张文华,高善玲,潘丽丽,刘超,刘冰熔,胡丽红,褚艳杰.肝硬化大鼠胃肠运动及胃动素受体表达的实验研究[J].胃肠病学和肝病学杂志,2014(2):162-165. |
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| 作者姓名： | 殷积彬 张文华 高善玲 潘丽丽 刘超 刘冰熔 胡丽红 褚艳杰 |
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| 作者单位： | [1]哈尔滨医科大学附属第二医院消化内科,黑龙江哈尔滨150086 [2]河北省沧州市人民医院消化内科 ,黑龙江哈尔滨150086 [3]哈尔滨医科大学附属第二医院研究生科,黑龙江哈尔滨150086 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（12511289） |
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| 摘 要： | 目的探讨肝硬化大鼠胃肠运动障碍与胃动素受体表达的关系。方法测定大鼠胃肠运动及十二指肠肌收缩力,测定胃肠道胃动素受体的表达。结果肝硬化大鼠与正常大鼠相比,在体胃肠排空时间明显延长(P0.05),离体十二指肠肌条平均收缩力明显减小(P0.05);肝硬化大鼠与正常大鼠相比胃动素受体染色浅,分布较少(P0.05)。结论肝硬化大鼠胃肠运动障碍与胃动素受体表达具有相关性。
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| 关 键 词： | 肝硬化 胃肠运动 十二指肠收缩力 胃动素 胃动素受体 |
Gastrointestinal movement and the expression of Motilin receptor in liver cirrhosis rats |
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| YIN Jibin,ZHANG Wenhua,GAO Shanling,PAN Lili,LIU Chao,LIU Bingrong,HU Lihong,CHU Yanjie.Gastrointestinal movement and the expression of Motilin receptor in liver cirrhosis rats[J].Chinese Journal of Gastroenterology and Hepatology,2014(2):162-165. |
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| Authors: | YIN Jibin ZHANG Wenhua GAO Shanling PAN Lili LIU Chao LIU Bingrong HU Lihong CHU Yanjie |
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| Institution: | 1. Department of Gastroenterology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086; 2. De- partment of Gastroenterology, Cangzhou People＇ s Hospital; 3. Department of Postgraduate, the Second Affiliated Hospital of Harbin Medical University, China) |
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| Abstract: | Objective To discuss the relationship between gastrointestinal movement disorders and Motilin receptor in liver cirrhosis rats. Methods Gastric emptying function and duodenal contraction force of rats were determined. The intensity and distribution of Motilin receptor in duodenal tissue were detected by immunohistochemistry. Results Gastric emptying time in live cirrhosis rats was longer than the control （P 〈 0.05）. Duodenal contraction force was smaller than that that in the control （P 〈 0.05）. The staining and distribution in liver cirrhosis were less than those in the control （P 〈 0.05）. Conclusion Gastrointestinal movement disorders in liver cirrhosis rats correlates with Motilin receptor. |
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| Keywords: | Liver cirrhosis Gastrointestinal movement Duodenal contraction force Motilin Motilin receptor |
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