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Shorter serial intervals in SARS-CoV-2 cases with Omicron BA.1 variant compared with Delta variant,the Netherlands, 13 to 26 December 2021
Authors:Jantien A Backer  Dirk Eggink  Stijn P Andeweg  Irene K Veldhuijzen  Noortje van Maarseveen  Klaas Vermaas  Boris Vlaemynck  Raf Schepers  Susan van den Hof  Chantal BEM Reusken  Jacco Wallinga
Affiliation:1.Center for Infectious Disease Control, WHO COVID-19 reference laboratory, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; 2.Saltro Diagnostic Center for Primary Care, Utrecht, The Netherlands; 3.Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands; 4.SYNLAB, Heppignies, Belgium; 5.Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
Abstract:
The SARS-CoV-2 Omicron variant has a growth advantage over the Delta variant because of higher transmissibility, immune evasion or shorter serial interval. Using S gene target failure (SGTF) as indication for Omicron BA.1, we identified 908 SGTF and 1,621 non-SGTF serial intervals in the same period. Within households, the mean serial interval for SGTF cases was 0.2–0.6 days shorter than for non-SGTF cases. This suggests that the growth advantage of Omicron is partly due to a shorter serial interval.
Keywords:SARS-CoV-2   COVID-19   Omicron variant   serial interval   Incubation period   transmission pairs
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