| 槲皮素磷酸酯钾对实验性心肌梗塞的影响 |
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| 引用本文： | 汤允昭,陶然,郝一彬,张萍,王志平,梁克军.槲皮素磷酸酯钾对实验性心肌梗塞的影响[J].中国药理学通报,1992(1). |
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| 作者姓名： | 汤允昭 陶然 郝一彬 张萍 王志平 梁克军 |
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| 作者单位： | 山西医学院药理教研室 太原030001
(汤允昭，陶然，郝一彬，张萍，王志平)，厦门鱼肝油厂 福建361005(梁克军) |
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| 摘 要： | iv10～20mg/kg(木解)皮素磷酸酯钾使兔急性心肌梗塞范围明显缩小,ST段明显降低,并能对抗冠脉结扎后引起的血清CPK含量增加及心律失常,这些作用与普萘洛尔相似。但iv40mg/kg后作用不明显。
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| 关 键 词： | 檞皮素磷酸酯钾 实验性心肌梗塞 肌酸磷酸激酶 普萘洛尔 |
EFFECTS OF PQP ON EXPERIMENTAL MYOCARDIAL INFARCTION IN RABBITS |
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| Tang Yunzhao,Tao Ran,Hao Yibin et al.EFFECTS OF PQP ON EXPERIMENTAL MYOCARDIAL INFARCTION IN RABBITS[J].Chinese Pharmacological Bulletin,1992(1). |
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| Authors: | Tang Yunzhao Tao Ran Hao Yibin |
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| Abstract: | Potassium quercetin phosphate ( PQP, iv 10~20mg/kg ) significantly decreased the size of infarction and S-T segment elevation induced by coronary artery ligation in rabbits (P<0.05), meanwhile PQP could reduce the plasma CPK activity and ventricular arrhythmias induced by coronary artery ligation (P<0.05). These effects are similar to those of propranolol. But PQP (iv 40mg/kg) couldn't obviously influence them. The above results suggeste that PQP ( iv 10~20mg/kg ) is beneficial and safe in limitation of EMI size and antiarrhythmia. |
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| Keywords: | Potassium quercetin phosphate ( PQP ): Experimental myocardial infarction ( EMI ) Creatine phosphokinase Propranolol |
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