| 水性巴布剂基质配方研究 |
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| 引用本文： | 李勇,何文,常聪,何杨虎,何平平.水性巴布剂基质配方研究[J].中国药师,2006,9(10):911-913. |
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| 作者姓名： | 李勇 何文 常聪 何杨虎 何平平 |
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| 作者单位： | 1. 武汉大学人民医院药学部,武汉,430060
2. 武汉大学药学院 |
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| 摘 要： | 目的:研究以卡波姆和聚丙烯酸钠作为水性巴布剂基质的最优配方。方法:通过正交设计实验,以配方中卡波姆、聚丙烯酸钠、PVPK30、CMCNa、PVA为因素,以用量为水平,设计L18(37)正交表,以内聚力、剥离强度作为考察指标。结果:配方中各因素对内聚力的作用大小依次为卡波姆、CMCNa、PVA,对剥离强度的作用大小依次为卡波姆、PVPK30、聚丙烯酸钠。结论:巴布剂基质的最优配方为卡波姆:聚丙烯酸钠:PVPK30∶CMCNa∶PVA=3．0∶4．0∶0．5∶0．2∶0．5。
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| 关 键 词： | 巴布剂 正交设计 卡波姆 聚丙烯酸钠 基质 |
| 文章编号： | 1008-049X（2006）10-0911-03 |
| 收稿时间： | 2006-03-27 |
| 修稿时间： | 2006-05-08 |
Study on Matrix of Hydrophilic Cataplasm |
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| Li Yong,He Wen,Chang Cong,He Yanghu,He Pingping.Study on Matrix of Hydrophilic Cataplasm[J].China Pharmacist,2006,9(10):911-913. |
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| Authors: | Li Yong He Wen Chang Cong He Yanghu He Pingping |
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| Abstract: | Objective: To optimize the matrix of hydrophilic cataplasm. Method: Content of carbomer, sodium polyacrylate, PVPK30, CMCNa and PVA were screened with adhesion strength and cohesive strength as indices by LI8(37) orthogonal design. Result : Results showed that adhesion strength could be affected by the contents of carbomer, CMCNa and PVA with order of carbomer > CMCNa > PVA (P < 0. 05) , and cohesive strength could be affected by the contents of carbomer, PVPK30 and sodium polyacrylate with order of carbomer > PVPK30 > sodium polyacrylate( P < 0. 05 ) . Conclusion: The best formula of hydrophilic cataplasm matrix could be carbomer: sodium polyacrylate: PVPK30: CMCNa: PVA = 3. 0: 4. 0:0.5: 0. 2:0.5. |
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| Keywords: | Cataplasma matrix Orthogonal design Carbomer Sodium polyacrylate |
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