| 载脂蛋白E基因多态性青年冠心病关系的研究 |
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| 引用本文： | 张典文,温淑珍,崔国方.载脂蛋白E基因多态性青年冠心病关系的研究[J].青岛医药卫生,2003(2). |
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| 作者姓名： | 张典文 温淑珍 崔国方 |
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| 作者单位： | 青岛市海慈医疗集团海慈医院 266033
(张典文，温淑珍)，青岛市海慈医疗集团海慈医院 266033(崔国方) |
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| 摘 要： | 目的 研究载脂蛋白E(apo E)基因多态性与青年冠心痛的相关关系。方法 采用聚舍酶链反应及限制性酶切技术来分析鉴别apo E基因第四外显子中含多态位点的DNA片断。结果 青年冠心病组E3/4基因型及E4等位基因频率明显高于对照组。结论apo E的E3/4基因型及E4等位基因与青年冠心病有关。
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| 关 键 词： | 载脂蛋白E 基因型 等位基因 冠心病 |
A Study of the Relationships Between Polymorphism of ApoE Gene and CHD in Young People |
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| Zhang Dianwen,et al..A Study of the Relationships Between Polymorphism of ApoE Gene and CHD in Young People[J].QINGDAO Medical Journal,2003(2). |
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| Authors: | Zhang Dianwen |
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| Institution: | Zhang Dianwen,et al. Qingdao Haiti Hospital,Qingdao 266033 |
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| Abstract: | Objective To investigate the co-relationships between polymorphism of apoE gene and coronary hear disease (CHD) in young people. Methods The polymorphic fragment of DNA in exon 4 of apoE gene was examined by pole-merase chain reaction(PCR)and restriction fragment length polymorphism(RFLP). Results The frequencies of E3/4 genotype and E4 allele in CHD of young people group were significantly higher than those in control group. Conclusion The E3/ 4 genotype and E4 allele of apoE were associated with CHD in young people. |
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| Keywords: | ApoE Genotype Allele Coronary heart disease |
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