不同通气障碍类型慢性阻塞性肺疾病患者伴发抑郁情绪的临床研究

目的探讨不同通气障碍类型慢性阻塞性肺疾病（COPD）患者出现抑郁情绪的情况。方法随机选取惠东县人民医院2009年10月至2012年8月诊治的稳定期COPD患者294例,根据肺功能通气性质分为阻塞性通气障碍组（n=135）和混合性通气障碍组（n=159）,采用美国流行病学研究中心抑郁量表（CES-D）评估两组患者的抑郁情况。结果从评价肺功能的依据实测值占预计值百分率的情况看,除肺总量（TLC）外其余指标两组比较差异均有统计学意义（P〈0.05）,按评判标准混合性通气障碍组肺通气功能较阻塞性通气障碍组为低,而肺气肿程度则较阻塞性通气障碍组严重;阻塞性通气障碍组患者抑郁情绪发生率仅为5.2%,可疑率为14.8%,均显著低于混合性通气障碍组的13.8%和32.1%,差异有统计学意义（P〈0.05）。结论呈混合性通气障碍的COPD患者抑郁情绪发生率较高,这可能与患病时间比较长、病变程度比较严重有关;临床上应重视对此类患者的治疗和随诊。

A clinical research of incidence rate of depression in chronic obstructive pulmonary disease patients of different type of ventilation disorder

Objective To investigate the incidence rate of depression in chronic obstructive pulmonary disease （COPD） patients of different type of ventilation disorder. Methods 294 patients who had undergone chronic obstructive pulmonary disease were selected randomly and divided into obstructive ventilatory disorder groups （135 cases） and mixed ventilatory disorder groups （159 cases）. The patients with depression in the two groups were assessed with CES-D. Results In addition to the value of TLC, the rest index are significant difference between the two groups depending on the evaluation of lung function according to the measured value of the percentage （P〈0.05）. Pulmonary ventilation function in mixed ventilatory disorder groups was significant lower than obstructive ventilatory disorder groups （P〈0.05）, but the degree of emphysema was serous in mixed ventilatory disorder groups. The incidence rate and Suspicious rate of depression in ventilatory disorder groups was 5.2% and 14.8% , significantly lower than mixed ventilatory disorder groups （P〈0.05）. Conclusions The COPD patients with mixed ventilatory disorder was more tend to depression, it was collected with the sick time and degree. It should patients more attention to those patients.