| 咪喹莫特微乳的制备及体外透皮评价 |
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| 引用本文： | 刘红,吴迪,谷亦平,周利娟,王宗春. 咪喹莫特微乳的制备及体外透皮评价[J]. 中国医药工业杂志, 2007, 38(7): 496-498 |
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| 作者姓名： | 刘红 吴迪 谷亦平 周利娟 王宗春 |
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| 作者单位： | 1. 湖北省医药工业研究院有限公司,湖北武汉,430061
2. 武汉大学人民医院,湖北武汉,430060 |
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| 摘 要： | 制备咪喹莫特微乳并考察其理化性质。载药微乳平均粒径为37.8nm,多分散指数为0.440。体外透皮试验表明,微乳8h累积渗透量明显高于咪喹莫特乳膏。
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| 关 键 词： | 咪喹莫特 微乳 透皮 |
| 文章编号： | 1001-8255（2007）07-0496-03 |
| 修稿时间： | 2006-09-15 |
Preparation and in vitro Transdermal Permeation of Imiquimod Microemulsion |
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| LIU Hong,WU Di,GU Yi-ping,ZHOU Li-juan,WANG Zong-chun. Preparation and in vitro Transdermal Permeation of Imiquimod Microemulsion[J]. , 2007, 38(7): 496-498 |
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| Authors: | LIU Hong WU Di GU Yi-ping ZHOU Li-juan WANG Zong-chun |
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| Affiliation: | 1. Hubei Pharmaceutical Industry Research Institute Co., Ltd., Wuhan 430061; 2. Renmin Hospital of Wuhan University, Wuhan 430060 |
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| Abstract: | The imiquimod microemulsion was prepared and the physicochemical properties were investigated. The mean particle size of the microemulsion was about 37.8nm with polydispersity index of 0.440. The accumulative amount of permeation in 8h through excised rabbit skin was significantly greater than that of the imiquimod cream. |
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| Keywords: | imiquimod microemulsion transdermal permeation |
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