|
|||||
|
|
HLA B44-restricted cytotoxic T lymphocyte responses to the peptides of HCV nucleoprotein residues 81–100 in patients with chronic hepatitis C |
|
| Authors: | Hiroto Kita Takashi Moriyama Takashi Kaneko Hiroaki Okamoto Kazumasa Hiroishi Shin Ohnishi Michio Imawari |
| Affiliation: | 1. Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan 2. Hepatology, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, 329-04, Tochigi, Japan 3. Immunology Divisions, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi-machi, Kawachi-gun, 329-04, Tochigi, Japan 4. Second Department of Internal Medicine, Faculty of Medicine, University of Showa, 1-5-8 Hatanodai, Shinagawa-ku, 142, Tokyo, Japan |
| Abstract: | Human leukocyte antigen B44-restricted cytotoxic T lymphocytes (CTLs) recognize an epitope in hepatitis C virus (HCV) nucleoprotein residues 81–100. CTLs that recognize two wild-type peptides 81–100 of HCV genotypes 1b/II and 2a/III were generated from peripheral blood lymphocytes of each of three patients studied. Although CTLs that recognize a wild-type peptide 81–100 of HCV genotypes 1a/I and 2b/IV were not generated from any patient, CTLs that recognize peptide 81–100 of a rate HCV isolate of type 1a/I were generated from two patients. The results suggest that HLA B44-restricted CTLs recognize most, if not all, HCV isolates of types 1b/II and 2a/III and rare variants of type 1a/I and that the wild-type HCV isolates of genotypes 1a/I and 2b/IV may be less immunogenic for HLA B44-restricted CTLs. |
| Keywords: | hepatitis C virus variant cytotoxic T lymphocyte HLA B44 |
| 本文献已被 SpringerLink 等数据库收录！ | |