Immunoreactive somatostatin-28(1-12) is increased in Huntington's disease |
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Authors: | M F Beal R Benoit E D Bird J B Martin |
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Affiliation: | 1. Department of Neurology, Massachusetts General Hospital, Boston, MA 02114 U.S.A.;2. McLean Hospital, Montreal, Que. Canada;3. the Montreal General Hospital Research Institute, Montreal, Que. Canada |
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Abstract: | Somatostatin-28(1-12) concentrations were measured in Huntington's disease (HD) postmortem tissue using a specific radioimmunoassay. Concentrations of immunoreactive somatostatin-28(1-12) were significantly increased in the caudate and putamen but were unchanged in cortical areas A9 and A17. Since somatostatin-28(1-12) terminates with the amino acids Arg-Glu-OH, we examined whether this dodecapeptide compound might exert a neurotoxic effect. Injections of somatostatin-28(1-12) into rat striatum showed no evidence of histologic damage. |
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Keywords: | Huntington's disease basal ganglia rat |
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