| 正交试验设计法优化吴茱萸炮制工艺的实验研究 |
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| 引用本文： | 张红梅,刘玉琴,姚金华,赵婷,王长虹,吴弢,王峥涛. 正交试验设计法优化吴茱萸炮制工艺的实验研究[J]. 上海中医药大学学报, 2008, 22(2): 59-61 |
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| 作者姓名： | 张红梅 刘玉琴 姚金华 赵婷 王长虹 吴弢 王峥涛 |
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| 作者单位： | 上海中医药大学中药研究所,中药标准化教育部重点实验室,上海201203;上海市中药标准化研究中心,上海201210;新疆医科大学第二附属医院药剂科,新疆,乌鲁木齐830028;上海华鹰药业有限公司,上海,201500 |
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| 基金项目： | 上海市科委科研基金资助项目(04DZ19851,05DZ19742):上海市重点学科建设资助项目(Y0301) |
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| 摘 要： | 目的：优化甘草制吴茱萸的炮制工艺参数，为制吴茱萸的炮制工艺提供科学依据。方法：采用HPLC法测定吴茱萸碱和吴茱萸次碱的含量，以两种生物碱总含量为评价指标，采用正交试验设计确定最佳甘草制吴茱萸的炮制工艺。结朵：甘草制吴茱萸的最佳炮制工艺为甘草用量6．25％，干燥温度60％，干燥时间9h。结论：本实验确定制吴茱萸的甘草用量为6．25％，与《上海市中药炮制规范》一致，为甘草制吴茱萸的炮制工艺提供了科学的实验依据，分析方法合理、准确、可靠。
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| 关 键 词： | 吴茱萸 甘草 吴茱萸碱 吴茱萸次碱 正交试验设计 高效液相色谱法 |
| 文章编号： | 1008-861X(2008)02-0059-03 |
| 修稿时间： | 2007-12-03 |
Optimization of Processing Technology for Fructus Evodiae with Orthogonal Test |
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| ZHANG Hong-mei,LIU Yu-qin,YAO Jin-hua,ZHAO Ting,WANG Chang-hong,WU Tao,WANG Zheng-tao. Optimization of Processing Technology for Fructus Evodiae with Orthogonal Test[J]. Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai, 2008, 22(2): 59-61 |
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| Authors: | ZHANG Hong-mei LIU Yu-qin YAO Jin-hua ZHAO Ting WANG Chang-hong WU Tao WANG Zheng-tao |
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| Affiliation: | ZHANG Hong-mei, LIU Yu-qin, YA0 Jin-hua, ZHA0 Ting, WANG Chang-hong, WU Tao,WANG Zheng-tao(1. Key Laboratory of Standardization of Chinese Medicines, Ministry of Education; Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine;2. Shanghai R＆D Centre for Standardization of Traditional Chinese Medicine;3. Department of Pharmacy, Second Hospital Affiliated to Xinjiang Medical University;4. Shanghai Huaying Pharmaceutical Co. Ltd) |
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| Abstract: | Objective： To optimize the parameters of processing technology for Fructus Evodiae and provide scientific reference for processing of Fructus Evodiae. Methods： The contents of evodiamine and rutaecarpine in Fructus Evodiae were determined with HPLC, and the total yields of the two alkaloids were chosen as the evaluating indicator. The orthogonal test was adopted to acquire the optimum technology for processing Fructus Evodiae with Radix Glycyrrbizae. Result： The study showed that the best parameters of processing technology for Fructus Evodiae was as follows： the dosage of Radix Glycyrrbizae was 6.25%, and the dry- ing temperature and time were 60℃ and 9 hours. Conclusion： The dosage of Radix Glycyrrbizae ascertained by this study coincides with that of ＂processing guidelines of Chinese Materia Medica in Shanghai＂. The study provids scientific references for pro- cessing Fructus Evodiae with Radix Glycyrrbizae and the method is reasonable, accurate and reliable. |
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| Keywords: | Fructus Evodiae Radix Glycyrrhizae evodiamine rutaecarpine orthogonal test HPLC |
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