| 重庆汉族人群 HPA 1-7、15多态性分布 |
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| 引用本文： | 毛伟,王芳,王跃华,黄霞,宋正利,张蕾,程磊. 重庆汉族人群 HPA 1-7、15多态性分布[J]. 重庆医学, 2009, 38(12) |
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| 作者姓名： | 毛伟 王芳 王跃华 黄霞 宋正利 张蕾 程磊 |
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| 作者单位： | 重庆市血液中心,400015;重庆市血液中心,400015;重庆市血液中心,400015;重庆市血液中心,400015;重庆市血液中心,400015;重庆市血液中心,400015;重庆市血液中心,400015 |
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| 摘 要： | 目的 了解重庆地区汉族人群人类血小板抗原(HPA)1-7、15抗原分布的多态性.方法 采用PCR-SSO技术对重庆地区无血缘关系的血小板无偿捐献者进行HPA1-7、15 HPA基因分型.结果 HPA各等位基因的频率分别为HPA-1a:0.995 3、HPA-1b:0.004 7;HPA-2a:0.936 2、HPA-2b:0.063 8;HPA-3a:0.575 0、HPA-3b:0.425 0;HPA-4a:0.996 2、HPA-4b:0.003 8;HPA-5a:0.941 8、HPA-5b:0.058 2;HPA-6a:0.985 9、HPA-6b:0.014 1;HPA-7a:1.000 0、HPA-7b:0.000 0;HPA-15a:0.541 3、HPA-15b:0.458 7.结论 重庆地区HPA基因频率呈现其自身的特点.应建立本地区的血小板供者分型数据库.
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| 关 键 词： | 人类血小板抗原 HPA 基因分型 基因频率 多态性 |
Polymorphism of HPA1-7,15 antigens in Chongqing Han population |
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| MAO Wei,WANG Fang,WANG Yue-hua,et al.. Polymorphism of HPA1-7,15 antigens in Chongqing Han population[J]. Chongqing Medical Journal, 2009, 38(12) |
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| Authors: | MAO Wei WANG Fang WANG Yue-hua et al. |
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| Affiliation: | MAO Wei,WANG Fang,WANG Yue-hua,et al.(Chongqing Blood Center,Chongqing,400015,China) |
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| Abstract: | Objective To investigate the polymorphism of HPA1-7,15 antigens in Chongqing Han population.Methods Samples from unrelated platelet donors in Chongqing were genotyped with PCR-SSO technique.Results The allele frequencies of HPA-1a,HPA-1b,HPA-2a,HPA-2b,HPA-3a,HPA-3b,HPA-4a,HPA-4b,HPA-5a,HPA-5b,HPA-6a,HPA-6b,HPA-7a,HPA-7b,HPA-15a,HPA-15b were 0.995 3,0.004 7,0.936 2,0.063 8,0.575 0,0.425 0,0.996 2,0.003 8,0.941 8,0.058 2,0.985 9,0.014 1,1.000 0,0.000 0,0.541 3,0.458 7,respectively.Conclusion HPA distribution ... |
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| Keywords: | HPA |
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