空腹血糖与血清瘦素、白细胞介素6的关系

目的研究空腹血糖与血清瘦素（LEP）、白细胞介素6（IL-6）水平的关系。方法将受试者258例根据空腹血糖（FPG）值分组：A组为FPG≤5．0mmol／L者65例,B组为5．0mmol／L〈FPG〈5．6mmol／L者67例,C组为5．6mmol／L≤FPG〈6．1mmol／L者64例,D组为6．1mmol／L≤FPG〈7．0mmol／L者62例。以上四组均检测FPG和空腹胰岛素（FINS）,并计算胰岛素抵抗指数（HOMA-IR）;检测血清LEP、IL-6、总胆固醇（TG）、甘油三酯（TC）、高密度脂蛋白胆固醇（HDL-C）。结果①各组随着FPG的升高,HOMA-IR、血清LEP水平明显升高。②各组内血清LEP水平女性明显高于男性（P〈0．01）。③血清LEP与FPG、FINS、HOMA—IR呈正相关（P〈0．01或〈0．05）。结论LEP参与了FPG升高、胰岛素抵抗的发生和发展,尤其在男性T2DM的发生过程中发挥着更为重要的作用。

Relationship among fasting blood glucose, serum Leptin and interleukin-6

Objective To study the relationship of fasting blood glucose, serum leptin（LEP） and interleukin-6. Methods According to the levels of fasting plasma glucose （FPG） , the 258 subjects were divided into 4 groups; Group A： 65 cases FPG≤5.0 mmol/L; GroupB： 67 cases 5.0 mmol/L 〈 FPG 〈5.6 mmol/L; GroupC： 64 cases 5.6 mmol/L≤ FPG 〈 6.1 mmol/L; GroupD ： 62 cases 6.1 mmol/L≤ FPG 〈 7.0 mmol/L. The levels of FPG and fasting insulin （Fins） in four groups were detected and insulin resistance index （HOMA-IR）were accounted. The levels of LEP, total cholesterol （TG） ,triglyceride （TC） and HDL cholesterol （ HDL-C ） in serum were measured. Results （1） The levels of HOMA-IR and LEP rose with elevating of levels of FPG.（2）The levels of LEP in serum of female groups was higher than that of the male groups in four groups （P 〈 0.01 ）. （3）The levels of LEP, FPG, FINS, HOMA-IR were positively related （P 〈 0.01, P 〈 0.05 ）. Conclusions LEP participates in the FPG elevating, insulinresistanee occurrence, thus plays an important role in the masculine T2DM occurrence process.