哮喘患儿血清IL-17与IL-8水平及相关性分析

目的：通过测定哮喘患儿血清中白细胞介素-17（IL-17）、白细胞介素-8（IL-8）水平及相关性,探讨其在哮喘免疫学发病机制中的作用。方法：采用ELISA法测定50例哮喘患儿及30例健康儿童血清中IL-17及IL-8水平,并进行相关分析。结果：哮喘组血清中IL-17水平与正常对照组相比明显升高,差异具有显著性（t=2.156,P〈0.05）;哮喘组血清中IL-8水平与正常对照组相比升高,差异具有显著性（t=2.463,P〈0.05）;直线相关分析表明,哮喘患儿血清中IL-17与IL-8水平之间无相关性（n=33,r=0.234,P〉0.05）。结论：IL-17及IL-8两者均可能参与了哮喘的发病过程。

Serum Levels of Interleukin-17 and Interluekin-8 in Children with Asthma and Their Relationship

Objective： To determine serum levels of interluekin-17（IL-17） and interluekin-8（IL-8） in children with asthma and analyze their relationship,and so as to explore the roles of IL-17 and IL-8 in immune pathogenesis of asthma.Methods： Serum levels of IL-17 and IL-8 in 50 asthma children and 30 healthy children were detected respectively with enzyme linked immunosorbent assay（ELISA）.The correlation of serum IL-17 with IL-8 were analyzed.Results： The serum levels of IL-17 and IL-8 in children with asthma（6.48,7.98 pg/ml,and 23.45,25.73 pg/ml） were higher than those of control group（5.95,5.54 pg/ml,and 22.94,5.41 pg/ml） respectively,and the differences were significant（t=2.156,P﹤0.05,and t=2.463,P﹤0.05）.The linear analysis showed that there was no correlation between serum levels of IL-17 and IL-8 in children with asthma（P〉0.05）.Conclusions： IL-17 and IL-8 may be involved in the immune pathogenesis of asthma in children.