应用ET技术检测高血压患者药物干预前后的颈动脉弹性功能

目的 探讨血管回声跟踪（ET）技术检测不同病程高血压病患者药物干预前后颈动脉弹性功能的变化及意义。方法 选取临床高血压病患者124例，其中短病程组57例，长病程组67例，应用药物进行治疗使其血压降至140/90mmHg以下，同时运用ET技术检测两组患者用药前后颈动脉弹性指标：僵硬度参数（β）、压力应变弹性系数（Ep）、动脉顺应性（AC）、脉搏波放大指数（AI）、脉搏波传递速度（PVWβ），并选取健康查体者44例作为对照组进行比较。结果 与对照组比较，不同病程高血压患者用药前参数β、Ep、AC、AI、PVWβ的差异均有统计学意义（短病程组P＜0.05，长病程组P＜0.01）；药物干预使血压降至标准值以下，与用药前比较，两组患者各项指标的差异除AI外均有统计学意义（P＜0.05）；两组患者用药前后β、Ep、AC和PVWβ变化率的差异有统计学意义（P＜0.05）。结论 药物干预能够改善高血压病患者的颈动脉弹性，病程不同，效果不同，运用ET技术能够检测并定量反映这一变化。

Elasticity of the carotid artery in hypertensive patients determined by the echo-tracking technique following drug intervention

Objectiv  To explore the effect of the echo tracking (ET) technique in determining the carotid elasticity in hypertensive (HBP) patients with different courses following drug therapy. Methods  With the ET technique, the carotid β, Ep, AC, AI and PVWβ of HBP patients were calculated pre- and post-treatment. A total of 124 HBP cases were divided into two groups: the short-course group (≤1 year, 57 cases) and the long course group(＞1 year, 67 cases). Another 44 healthy adults served as the controls. The parameters were compared between the control group and the HBP group, between the short-course group and the long course group as well as between the pre-treatment group and the post-treatment group. Results Compared with the control group, the β， Ep， AC， AI and PVWβ were different in HBP patients before and after drug treatments. After drug intervention, the levels of β， Ep, PVWβ were decreased and AC was significantly increased in the HBP group (P＜0.05), and these changes were significant in the short course group. There was no difference of AI in HBP patients before and after drug intervention (P＞0.05). Conclusions  Drug intervention improves the carotid elasticity of HBP patients, and the earlier, the better, which can be shown by the ET technique．