| 调补气血针法对SAMP10脑中枢神经递质含量影响的研究 |
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| 引用本文： | 王彤,庞莹,丁晓蓉,于涛,刘庆忠,王舒,韩景献.调补气血针法对SAMP10脑中枢神经递质含量影响的研究[J].辽宁中医杂志,2003,30(8):663-664. |
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| 作者姓名： | 王彤 庞莹 丁晓蓉 于涛 刘庆忠 王舒 韩景献 |
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| 作者单位： | 天津中医学院第一附属医院老年病研究室,天津,300193 |
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| 摘 要： | 目的 :旨在揭示调补气血针法治疗痴呆的中枢作用机制。方法 :采用HPLC -ECD法对SAMP10及SAMR1脑组织单胺类神经递质和乙酰胆碱 (Ach)含量进行测定。结果 :①SAMP10脑组织DA、5 -HT、Ach的含量显著低于SAMR1的含量 ;②调补气血针法可使脑组织降低的DA、5 -HT、Ach的含量显著提高。结论 :①SAMP10小鼠的学习、记忆障碍发病机制之一可能是脑组织Ach和单胺类神经递质的代谢异常出现了神经损害 ;②调补气血针法改善了SAMP10的学习、记忆状况
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| 关 键 词： | 自然快速老化脑萎缩及痴呆模型小白鼠(SAMP10) 调补气血针法 中枢神经递质 实验研究 |
| 文章编号： | 1000-1719(2003)08-0663-02 |
| 修稿时间： | 2003年3月17日 |
Study on Tiao Bu Qi Xue Acupuncture Acting on the Changes of Central Neurotransmitter in the Brain |
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| WANG Tong,PANG Ying,DING Xiao rong,YU Tao.Study on Tiao Bu Qi Xue Acupuncture Acting on the Changes of Central Neurotransmitter in the Brain[J].Liaoning Journal of Traditional Chinese Medicine,2003,30(8):663-664. |
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| Authors: | WANG Tong PANG Ying DING Xiao rong YU Tao |
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| Abstract: | Objective :to explore the effects of Tiao Bu Qi Xue acupuncture principle on the changes of central neurotransmitter in the brain. Method :The amount of Monoamine neurotransmitter and Ach in SAMP10 and SAMR1 brain is observed by high-performance liquid chromatograph with electrochemical detector method (HPLC-ECD). Results :①The amount of DA,5-HT and Ach in SAMP10 brain is greatly lower than those of SAMR1.②The amount of DA,5-HT and Ach in Tiao Bu Qi Xue group increased more significantly than those in the SAMP10 group. Conclusion :①The abnormal metabolism of Monoamine neurotransmitter and Ach in brain is one mechanism of SAMP10 to learn and memorize declining.②Tiao Bu Qi Xue acupuncture principle improved ability of SAMP10 to learn and memorize. |
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| Keywords: | Senescence Accelerated Mouse (SAMP10) Tiao Bu Qi Xue acupuncture principle central neurotransmitter experimental study |
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