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| 单麻叶千里光中肝毒吡咯里西啶生物碱的分离与鉴定 | |
| 引用本文： | 马鸿雁,杨莉,王长虹,王峥涛. 单麻叶千里光中肝毒吡咯里西啶生物碱的分离与鉴定[J]. 中国中药杂志, 2011, 36(2): 166-168 |
| 作者姓名： | 马鸿雁 杨莉 王长虹 王峥涛 |
| 作者单位： | 1. 上海中医药大学中药研究所,中药标准化教育部重点实验室,中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海市复方中药重点实验室,上海,201203;广东药学院中药学院,广东,广州,510005 2. 上海中医药大学中药研究所,中药标准化教育部重点实验室,中药新资源与质量标准综合评价国家中医药管理局重点研究室,上海市复方中药重点实验室,上海,201203 |
| 基金项目： | 国家自然科学基金项目(30701104);国家重点基础研究发展(973)计划项目(2006CB504704) |
| 摘 要： | 目的:研究菊科千里光属植物单麻叶千里光Senecio cannabifolius var.integrilifolius的肝毒性吡咯里西啶生物碱.方法:运用多种色谱方法进行分离纯化,应用现代波谱学分析方法进行结构鉴定.结果:从单麻叶千里光的总碱部位中分离得到4个吡咯里西啶生物碱,分别鉴定为:jacobine(1),jacoline(2),jaconine(3),senecicannabine(4).结论:化合物1～4均为首次从该植物中分离得到. |
| 关 键 词： | 单麻叶千里光 化学成分 吡咯里西啶生物碱 |
| 收稿时间： | 2010-04-27 |
Pyrrolizidine alkaloids of Senecio cannabifolius var. integrilifolius |
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| MA Hongyan,YANG Li,WANG Changhong and WANG Zhengtao. Pyrrolizidine alkaloids of Senecio cannabifolius var. integrilifolius[J]. China Journal of Chinese Materia Medica, 2011, 36(2): 166-168 | |
| Authors: | MA Hongyan YANG Li WANG Changhong WANG Zhengtao |
| Affiliation: | Key Laboratory for Standardization of Chinese Medicines and State Administration of Traditional Chinese Medicine, Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Guangdong Pharmaceutical University, Guangzhou 510000, China;Key Laboratory for Standardization of Chinese Medicines and State Administration of Traditional Chinese Medicine, Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Key Laboratory for Standardization of Chinese Medicines and State Administration of Traditional Chinese Medicine, Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Key Laboratory for Standardization of Chinese Medicines and State Administration of Traditional Chinese Medicine, Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory for Compound Chinese Medicines, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| Abstract: | Objective : To study the pyrrolizidine alkaloids of Senecio cannabifolius var. integrilifolius. Method : Various chromatographic methods were used for the isolation and purification of chemical constitutents of the plant and their structures were elucidated on the basis of spectral analysis. Result : Four compounds were determinated as jacobine( 1 ),jacoline( 2 ), jaconine( 3 ), senecicannabine( 4 ). Conclusion : All compounds were isolated from this plant for the first time. |
| Keywords: | Senecio cannabifolius var. integrilifolius chemical constituents pyrrolizidine alkaloids. |
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