AVP V1受体阻断剂对昼光和暗光中正常大鼠体温的影响

目的: 研究内源性精氨酸加压素(AVP)是否参与正常的体温调节过程。方法: 用无线体温遥测仪测量大鼠的体温变化,观察腹腔注射AVPV₁受体阻断剂对昼光和暗光中(明∶暗=12∶12)大鼠体温的影响。结果: 腹腔注射AVPV₁受体阻断剂可明显提高大鼠的正常体温,在昼光中(6:00AM-6:00PM)体温升高持续的时间长达6h,雄性大鼠的体温明显高于雌性的体温。在暗光中(6:00PM-6:00AM),AVPV₁受体阻断剂只使进入暗光初期的大鼠体温升高,持续的时间为2h,雄性和雌性之间无明显差别。结论: AVPV₁受体阻断剂可使正常大鼠体温升高,实验结果提示内源性AVP对正常体温有紧张性调节作用。

Effect of AVP V1-receptor antagonist on normal body temperature in rats under light-dark cycle

AIM: To assess if endogenous arginine vasopressin is involved in normal thermoregulatory processes. METHODS: Core temperature was monitored in undisturbed rats using radiotelemetry. Effect of AVP V 1 antagonist on normal body temperature were observed in rats under a 12:12 light-dark cycle. RESULTS: Intraperitoneal injection of AVP V 1-receptor antagonist in rats induced a increase in normal body temperature. Under normal light (light on at 6:00 AM-6:00 PM), AVP V 1 antagonist induced a increase in body temperature persisting for about 6 hour, but male rats had higher hyperthermia than female. Under normal dark exposure (light off at 6:00 PM- 6:00 AM), AVP V 1-receptor antagonist caused a increase in body temperature persisting for about 2 hour at the start of the dark phase, but no difference was found between sexes. CONCLUSION: Intraperitoneal injection of AVP V 1-receptor antagonist caused a increase in normal body temperature. The data indicated that endogenous vasopressin could be involved in tonic thermoregulatory process.