| L-精氨酸和牛磺酸对同型半胱氨酸诱导平滑肌细胞增殖的抑制作用 |
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| 引用本文： | 薛林,张钧华,李载权,庞永正,唐朝枢,刘乃奎.L-精氨酸和牛磺酸对同型半胱氨酸诱导平滑肌细胞增殖的抑制作用[J].中国介入心脏病学杂志,1999(4). |
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| 作者姓名： | 薛林 张钧华 李载权 庞永正 唐朝枢 刘乃奎 |
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| 作者单位： | 北京医科大学第一附属医院心血管研究所!１０００３４(薛林，张钧华，李载权，庞永正)，北京医科大学心血管基础研究所(唐朝枢，刘乃奎) |
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| 摘 要： | 目的 观察Ｌ－精氨酸和牛磺酸对同型半胱氨酸（ＨＣＹ）诱导的血管平滑肌细胞（ＶＳＭＣ）增殖的影响。方法采用同位素技术测定ＶＳＭＣ３Ｈ－ＴｄＲ参入。结果ＨＣＹ可促进ＶＳＭＣ增殖。Ｌ－精氨酸及牛磺酸均可呈剂量依赖性抑制ＨＣＹ诱导的ＶＳＭＣ增殖，且合用Ｌ－精氨酸和牛磺酸的对ＶＳＭＣ增殖的抑制作用明显强于单纯应用Ｌ－精氨酸或牛磺酸组。结论Ｌ－精氨酸和牛磺酸均可抑制ＨＣＹ诱导的ＶＳＭＣ增殖。
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| 关 键 词： | 半胱氨酸 牛磺酸 L－精氨酸 肌、平滑肌 血管／药理作用 |
The inhibitory effects of L-arginine and taurine on homocysteine-induced vascular smooth muscle cell proliferation |
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| Xue Lin, Zhang Junhua, Li Zaiquan et al..The inhibitory effects of L-arginine and taurine on homocysteine-induced vascular smooth muscle cell proliferation[J].Chinese Journal of Interventional Cardiology,1999(4). |
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| Authors: | Xue Lin Zhang Junhua Li Zaiquan |
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| Abstract: | Objective To investigate influence of L-arginine and taurine on homocysteine (HCY)induced vascular smooth muscle cell (VSMC) proliferation. Methods 3H-TdR incorporation was assayed with isotopic methed. Results HCY induced VSMC proliferation. L-arginine and taurine inhibited HCY-induced VSMC proliferation in a dose dependent manner. In addition, inhibitory effects of Larginine and taurine on VSMC proliferation was stronger significantly than L-arginine or taurine alone.Conclusion L-arginine and taurine inhibited HCY-induced VSMC proliferation. |
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| Keywords: | Cysteine L-arginine Taurine Muscular smooth vascular/drug eff |
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