重症COPD人群脂代谢紊乱与CRP水平变化的临床分析

目的:观察重症慢性阻塞性肺疾病(COPD)人群脂代谢紊乱与CRP水平的变化,探讨其对预后的影响。方法:97例健康体检者为对照组,85例重症COPD人群为观察组,采用全自动生化分析仪测定甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、ApoA1/ApoB、HDL-C/LDL-C、HDL-C/TC、脂蛋白a(Lipa)浓度;采用免疫散射比浊法测定CRP水平。结果:观察组人群TG、CRP水平明显高于对照组;HDL-C、ApoA1、Lipa浓度明显低于对照组,差别均有统计学意义;经多元回归分析重症COPD人群血清脂质代谢水平与CRP水平密切相关。结论:重症COPD人群脂代谢发生紊乱,血清TG、CRP水平明显升高,HDL-C、ApoA1、Lipa浓度明显降低,其脂代谢水平与CRP密切相关;早期诊断及时治疗与预后密切相关,诊治过程中应控制脂代谢紊乱与CRP变化并加强护理,提高治疗效果,改善预后,防止或延缓心血管疾病等并发症发生。

Clinical analysis of relationship between lipid metabolic disorder and CRP levels in patients with severe chronic obstructive pulmonary disease

Objective:To observe the changes of lipid metabolic disorder and CRP levels in patients with severe chronic obstructive pulmonary disease(COPD),and to explore their effect on prognosis.Methods: 97 healthy people acted as control group,85 patients with severe COPD served as observation group.The concentrations of triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB),ApoA1/ApoB,HDL-C/LDL-C,HDL-C/TC and lipoprotein a(Lipa) in control group and observation group were determined with automatic biochemical analyzer,while the CRP levels were measured by immunity-turbidity method.Results: The TG and CRP levels of observation group were significantly higher than those of the control group,and the HDL-C,ApoA1 and Lipa concentrations of observation group were significantly lower than those of the control group,the differences all had statistical significances.Multiple regression analysis showed that the serum lipid metabolism level was closely related to the CRP levels in patients with severe COPD.Conclusion: The lipid metabolism disorder was found in severe COPD patients,serum TG and CRP levels significantly increased,while the HDL-C,AproA1 and Lipa concentrations significantly decreased,the lipid metabolism levels and CRP levels were closely related.Early diagnosis and timely treatment had close relationship with prognosis,the lipid metabolism disorder and CRP levels during the diagnosis and treatment process should be controlled and enhanced care,which can improve the therapeutic effect and prognosis,prevent or delay cardiovascular disease and other complications.