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| 青藤碱对胶原诱导性关节炎大鼠滑膜细胞凋亡的影响 | |
| 引用本文： | 黄清春,陈纪藩,陈光星,叶柳忠,刘清平,李晓娟. 青藤碱对胶原诱导性关节炎大鼠滑膜细胞凋亡的影响[J]. 中国组织工程研究与临床康复, 2002, 6(17): 2541-2541 |
| 作者姓名： | 黄清春 陈纪藩 陈光星 叶柳忠 刘清平 李晓娟 |
| 作者单位： | 1. 解放军广州军区广州总医院,广东,广州,510010 2. 广州中医药大学,广东,广州,510282 |
| 基金项目： | 国家自然科学基金重点项目资助(39930230) |
| 摘 要： | 目的研究青藤碱对Ⅱ型胶原蛋白诱导性大鼠关节模型(CIA)滑膜细胞凋亡的影响。方法原位细胞凋亡检测试剂盒检测各组原代大鼠滑膜细胞凋亡的水平。结果青藤碱组CIA大鼠滑膜细胞的凋亡数明显增加。结论青藤碱治疗类风湿性关节炎的机制可能与诱导滑膜细胞凋亡有关。 |
| 关 键 词： | 类风湿性关节炎 滑膜细胞 培养 凋亡 青藤碱 |
| 文章编号： | 1671-5926(2002)17-2541-02 |
| 修稿时间： | 2002-06-06 |
Effect of sinomenine on apoptosis of synoviocytes in CIA rats |
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| HUANG Qing-chun,CHEN Ji-fan,CHEN G uang-xing,et al.. Effect of sinomenine on apoptosis of synoviocytes in CIA rats[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2002, 6(17): 2541-2541 | |
| Authors: | HUANG Qing-chun CHEN Ji-fan CHEN G uang-xing et al. |
| Affiliation: | HUANG Qing-chun,CHEN Ji-fan,CHEN G uang-xing,et al.Guangzhou General Hospital of PL A,Guangzhou 510010,China |
| Abstract: | Objective To study the effect of si no menine on a poptosis of synoviocytes in CIA rats.Methods The level of the apop tosis in different groups were assayed by the in situ cell death detection kit. Results Sinomenine could induce apoptosis o f synoviocytes in CIA rats.Conclusi on The mechanism of curative effect of s inomenine on arthritis concern with ris ing the level of apoptosis. |
| Keywords: | rheumatoid synovial membrane cul ture apoptosis sinomenine |
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