| 2-巯基-5-甲氧基-1H-苯并咪唑的制备 |
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| 引用本文： | 戴桂元,刘德龙,胡涛,刘蕴. 2-巯基-5-甲氧基-1H-苯并咪唑的制备[J]. 中国医药工业杂志, 2003, 34(2): 60-61 |
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| 作者姓名： | 戴桂元 刘德龙 胡涛 刘蕴 |
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| 作者单位： | 徐州师范大学化学系,江苏徐州,221009 |
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| 摘 要： | 以对乙酰氨基酚为原料，经甲基化、硝化、水解得到4-甲氧基-2-硝基苯胺，Raney-N1催化下以水合肼还原后再与乙基黄原酸钾环缩合制得奥美拉唑重要中间体2-巯基-5-甲氧基-1H-苯并咪陛，总收率69％。
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| 关 键 词： | 咪唑 制备 奥美拉唑 中间体 2－巯基－5－甲氧基－1H－苯并咪唑 |
| 文章编号： | 1001-8255(2003)02-0060-02 |
| 修稿时间： | 2002-07-01 |
Preparation of 2-Mercapto-5-methoxybenzimidazole |
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| DAI Gui-Yuan,LIU De-Long,HU Tao,LIU Yun. Preparation of 2-Mercapto-5-methoxybenzimidazole[J]. , 2003, 34(2): 60-61 |
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| Authors: | DAI Gui-Yuan LIU De-Long HU Tao LIU Yun |
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| Abstract: | Mercapto-5-methoxybenzimidazole was synthesized from p-acetaminophenol by methyl- ation, nitration and hydrolysis to give 2-nitro-4-methoxyaniline, which was reduced by hydrazine hydrate using Raney-Ni as catalyst and followed by cyclocondensation with potassium ethyl xanthate in one pot to give the title compound with an overall yield of 69%. |
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| Keywords: | mercapto-5-methoxybenzimidazole omeprazole intermediate synthesis |
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