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| 血浆白介素-37水平与冠状动脉钙化相关性研究 | |
| 引用本文： | 吉庆伟,柴萌,刘宇扬,刘巍,方哲,王建龙,胡宾,葛海龙,周玉杰. 血浆白介素-37水平与冠状动脉钙化相关性研究[J]. 心肺血管病杂志, 2015, 0(2): 79-81 |
| 作者姓名： | 吉庆伟 柴萌 刘宇扬 刘巍 方哲 王建龙 胡宾 葛海龙 周玉杰 |
| 作者单位： | 首都医科大学附属北京安贞医院;北京市心肺血管疾病研究所心内12病房 |
| 基金项目： | 国家自然科学基金(81160045,81270285);北京市卫生系统高层次卫生技术人才队伍建设专项经费资助(2011-1-5);北京市医院管理局临床医学发展专项经费资助(ZY201303);国家临床重点专科建设项目资助;中国博士后科学基金(2013M540987);首都医科大学附属北京安贞医院院长科技发展基金(2013Z07) |
| 摘 要： | 目的:探讨冠状动脉钙化患者血浆白介素(IL)-37水平的变化。方法:入选行冠状动脉CT检查发现冠状动脉钙化的患者48例,无冠状动脉钙化的30例患者为对照组。采用夹心酶联免疫法(ELISA)测定血浆IL-37和肿瘤坏死因子(TNF)-α,采用乳胶凝集比浊法检测超敏C反应蛋白(hs-CRP)水平。结果:冠状动脉钙化患者血浆IL-37(80.81±26.21)ng/L、TNF-α(12.53±3.44)ng/L和hs-CRP(2.66±3.89)mg/L水平高于对照组[IL-37(65.91±20.55)ng/L,P=0.010;TNF-α(10.51±3.73)ng/L,P=0.017;hs-CRP(1.12±0.81)mg/L,P=0.035]。相关性分析显示冠状动脉钙化患者血浆IL-37与TNF-α、hs-CRP水平、冠状动脉钙化Agatston积分正相关(分别r=0.410,P=0.004;r=0.481,P=0.001;r=0.354,P=0.013)。结论:新型抗炎因子IL-37可能与冠状动脉钙化的发生、发展密切相关。 |
| 关 键 词： | 冠状动脉钙化 白介素-37 炎症反应 |
Elevated plasma IL-37 levels in patients with coronary artery calcification |
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| JI Qingwei;CHAI Meng;LIU Yuyang;LIU Wei;FANG Zhe;WANG Jianlong;HU Bin;GE Hailong;ZHOU Yujie. Elevated plasma IL-37 levels in patients with coronary artery calcification[J]. Journal of Cardiovascular and Pulmonary Diseases, 2015, 0(2): 79-81 | |
| Authors: | JI Qingwei CHAI Meng LIU Yuyang LIU Wei FANG Zhe WANG Jianlong HU Bin GE Hailong ZHOU Yujie |
| Affiliation: | JI Qingwei;CHAI Meng;LIU Yuyang;LIU Wei;FANG Zhe;WANG Jianlong;HU Bin;GE Hailong;ZHOU Yujie;Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases; |
| Abstract: | Objective: To evaluate the levels of interleukin( IL)-37,tumor necrosis factor( TNF)-αand high-sensitivity C-reactive protein( hs-CRP) in patients with coronary artery calcification( CAC). Methods: The plasma IL-37,TNF-α and hs-CRP levels were measured in 48 patients with CAC and 30 control patients without CAC. Results: The plasma IL-37,TNF-α and hs-CRP levels in patients with CA were significantly increased compared to those of the control group [IL-37( 80. 81 ± 26. 21) vs.( 65. 91 ± 20. 55) ng / L,P = 0. 010; TNF-α( 12. 53 ± 3. 44) vs.( 10. 51 ± 3. 73) ng / L,P = 0. 017; hs-CRP( 2. 66 ± 3. 89) vs.( 1. 12 ±0. 81) mg / L,P = 0. 035]. A correlation analysis showed that the plasma IL-37 levels were positively correlated with TNF-α( r = 0. 410,P = 0. 004),hs-CRP( r = 0. 481,P = 0. 001) and Agatston scores( r = 0. 354,P =0. 013). Conclusion: The novel anti-inflammatory cytokine IL-37 is independently associated with CAC. |
| Keywords: | Coronary artery calcification IL-37 Inflammation |
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