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| 高糖对大鼠主动脉血管平滑肌细胞产生一氧化氮及其合酶活性的影响 | |
| 引用本文： | 严金川,刘乃丰,陈日新. 高糖对大鼠主动脉血管平滑肌细胞产生一氧化氮及其合酶活性的影响[J]. 东南大学学报(医学版), 1998, 0(3) |
| 作者姓名： | 严金川 刘乃丰 陈日新 |
| 作者单位： | 南京铁道医学院心血管病研究室 |
| 摘 要： | 目的：研究高糖对主动脉血管平滑肌细胞产生一氧化氮（ＮＯ）及其合酶（ＮＯＳ）活性的影响。方法：应用ＮＯ及ＮＯＳ试剂盒测定大鼠主动脉血管平滑肌细胞ＮＯ的含量及ＮＯＳ的活性。结果：高糖能显著抑制培养的平滑肌细胞ＮＯ的产生，并能明显降低ＮＯＳ的活性，具有浓度和时间效应。结论：高糖对平滑肌细胞产生ＮＯ的抑制可能是通过抑制其ＮＯＳ的活性而起作用的。 |
| 关 键 词： | 高糖；血管平滑肌；细胞培养；一氧化氮；一氧化氮合酶；大鼠 |
Effects of High Glucose on NO Production and NOS Activity in Cultured Rat Aortic Vascular Smooth Muscle Cells |
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| Yan Jinchuan,Liu Naifeng,Chen Rixin. Effects of High Glucose on NO Production and NOS Activity in Cultured Rat Aortic Vascular Smooth Muscle Cells[J]. Journal of Southeast Univ: Medical Sci Ed, 1998, 0(3) | |
| Authors: | Yan Jinchuan Liu Naifeng Chen Rixin |
| Abstract: | Objective:To study the effect and mechanism of high glucose on NO and NOS activity producted in cultured rat aortic vascular smooth muscle cells.Method:The level of NO and NOS activity were measured by NO and NOS kits in ASMC.Result:High glucose significantly decrease NO production and the activity of NOS in a dose-and time-dependent manners in ASMC.Conclution:High glucose can markedly attenuate the NO synthesis, the possible mechanism of this effect was attributed to the decrease of NOS activity. |
| Keywords: | high glucose vascular smooth muscle cultured cells nitric oxide nitric oxide synthase rats |
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