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Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma |
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| Authors: | Kentaro Yokoi Masaharu Akiyama Takaaki Yanagisawa Junko Takahashi-Fujigasaki Yuichi Yokokawa Yoko Mikami-Terao Kohei Fukuoka Kohji Fujisawa Hiromichi Nakazaki Shizuo Oi Yoshikatsu Eto Hisashi Yamada |
| Affiliation: | (1) Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku Tokyo, 105-8461, Japan;(2) Department of Pediatric Neurosurgery, Jikei University School of Medicine, Tokyo, Japan;(3) Division of Neuropathology, Jikei University School of Medicine, Tokyo, Japan;(4) Department of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan |
| Abstract: | Introduction Cadherins are Ca2+-dependent cell-to-cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Cadherin involvement in tumor metastasis has recently been reported. Case report We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination. We observed low expression of E-cadherin in all surgical specimens and autopsy specimens. In contrast, expression of N-cadherin was high in all surgical specimens, but was decreased in autopsy specimens. Conclusion Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma. |
| Keywords: | Ependymoma Recurrence Dissemination N-cadherin |
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