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| 可切削生物活性玻璃陶瓷的致突变性研究 | |
| 引用本文： | 陈小平,宋建良,朱蔚精. 可切削生物活性玻璃陶瓷的致突变性研究[J]. 中华医学美学美容杂志, 2000, 6(3): 132-133 |
| 作者姓名： | 陈小平 宋建良 朱蔚精 |
| 作者单位： | 杭州市整形医院(陈小平!310014，宋建良!310014，焦亚平!310014，冯玉富!310014)，四川省生物医学材料监测中心(朱蔚精，彭蔷)，杭州市铁路中心医院(谭晓兴) |
| 摘 要： | 了解可切削生物活性玻璃陶瓷 (MBGC)的潜在致突变性。方法 采用微核试验。按照有关规定制备MBGC材料浸提液 ,将浸提液和阴性、阳性对照液分别注入各实验组小白鼠的静脉内 ,于第 2次注射后 6h取其骨髓涂片 ,双盲法观察骨髓嗜多染红细胞内的微核发生率。结果 MBGC浸提液的微核率分别为 (2 .4 1.7)‰和 (2 .2 1.3)‰ ,与阴性对照组生理盐水 (2 .6 0 .9)‰无显著性差异。结论 该材料未见潜在致突变性。 |
| 关 键 词： | 生物相容性材料 微核试验 致突变性 |
| 修稿时间： | 1999-09-13 |
Study on micronucleus test of bone marrow cells for mutagenicity of MBGC |
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| CHEN Xiaoping,SONG Jianliang,ZHU Weijing,et at. Hangzhou Plastic Surgery Hospital,Hangzhou,,China. Study on micronucleus test of bone marrow cells for mutagenicity of MBGC[J]. Chinese Journal of Medical Aesthetics and Cosmetology, 2000, 6(3): 132-133 | |
| Authors: | CHEN Xiaoping SONG Jianliang ZHU Weijing et at. Hangzhou Plastic Surgery Hospital Hangzhou China |
| Affiliation: | CHEN Xiaoping,SONG Jianliang,ZHU Weijing,et at. Hangzhou Plastic Surgery Hospital,Hangzhou,310014,China |
| Abstract: | Objective To evaluate the mutagenicity of machinable bioactive glass ceramics (MBGC) by micronucleus test of bone marrow. Methods The samples of MBGC extraction, negative control and passive control groups were injected in to the vein of the white rats. 6 hours after the last injection, the sections of bone marrow were made and the micronucleus viewed. Results MBGC micronucleus rate were (2.4 1.7) and (2.2 1.3). There was no significant difference on the rate of the micronucleus between the MBGC and the negative control group(2.6 0.9). Conclusion There is no potential mutagenicity for MBGC. |
| Keywords: | Biocompatible materials Micronucleus Mutage |
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