| 自身免疫性肝病患者自身抗体检测及临床意义 |
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| 引用本文： | 张利方,郑山根,周萍. 自身免疫性肝病患者自身抗体检测及临床意义[J]. 免疫学杂志, 2009, 25(2): 202-204,213 |
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| 作者姓名： | 张利方 郑山根 周萍 |
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| 作者单位： | 广州军区武汉总医院检验科,武汉,430070;广州军区武汉总医院检验科,武汉,430070;广州军区武汉总医院检验科,武汉,430070 |
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| 摘 要： | 目的 探讨自身免疫性肝病患者血清中出现的自身抗体等免疫学指标及临床意义.方法 对3 500例肝功能反复异常的患者采用间接免疫荧光法检测抗核抗体(ANA)、抗平滑肌抗体(SMA)、抗线粒体抗体(AMA).并对AMAM2型及抗可溶性肝抗原/肝胰抗原(抗SLA/LP)、抗肝肾微粒体抗体Ⅰ型(抗LKM-1)和抗肝特异性胞浆抗原Ⅰ型抗体(抗LC-1)等肝脏疾病相关的自身抗体进行检测.结果 3 500例患者中,自身免疫性肝炎患者29例,检出率为0.83%,其中符合Ⅰ型、Ⅱ型、Ⅲ型自身免疫性肝炎的比例占72.4%、10.3%和17.2%.原发性胆汁性肝硬化(PBC)患者58例,检出率为1.65%,血清中AMAM2型抗体阳性率为93.1%,其中19例AMAM2阳性患者进行肝穿病理检查时12例(63.7%)患者病理提示符合PBC诊断.结论 每种自身免疫性肝病都具有特征性自身抗体谱,注重自身抗体检测对明确诊断及鉴别诊断自身免疫性肝病具有重要的临床意义.
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| 关 键 词： | 自身免疫性肝病 自身抗体 间接免疫荧光法 免疫印迹法 |
Immunological characteristics of autoantibodies in autoimmune liver disease patients |
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| ZHANG Lifang,ZHENG Shangen,ZOU Ping. Immunological characteristics of autoantibodies in autoimmune liver disease patients[J]. Immunological Journal, 2009, 25(2): 202-204,213 |
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| Authors: | ZHANG Lifang ZHENG Shangen ZOU Ping |
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| Affiliation: | ZHANG Lifang,ZHENG Shangen,ZOU Ping Department of Clinical Laboratory,Wuhan General Hospital of Guangzhou Military Comm,,Wuhan 430070,China |
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| Abstract: | Objective To study the clinical significance of the immunological characteristics in patients with autoimmune liver disease.Methods Total of 3 500 patients with abnormal liver functions were examined for anti-nuclear antibodies(ANA),anti-mitochondria antibodies(AMA),and anti-smooth muscle antibodies(SMA)using immunofluorescent assays.Soluble liver antigen(SLA)/liver-pancreas antigen(LP),anti-liver kidney microtonal antibody-1(LKM-1),liver cytosolic-1(LC-1),subtype of AMA(M2),as well as ANA profile were dete... |
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| Keywords: | autoimmune liver disease autoantibodies indirect immunofluorescence assay immunoblot assay |
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