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| Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome： Retrospective analysis | |
| 引用本文： | Cui HJ,Tong XL,Li P,Hao YX,Chen XG,Li AG,Zhang ZY,Duan J,Zhen M,Zhang B,Hua CJ,Gong YW. Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome： Retrospective analysis[J]. World journal of gastroenterology : WJG, 2004, 10(11): 1652-1655. DOI: 10.3748/wjg.v10.i11.1652 |
| 作者姓名： | Cui HJ Tong XL Li P Hao YX Chen XG Li AG Zhang ZY Duan J Zhen M Zhang B Hua CJ Gong YW |
| 摘 要： | |
| 关 键 词： | 免疫血清 肝脏酶表达 急性呼吸窘迫综合征 SARS 非典型肺炎 AST ALT |
| 收稿时间： | 2003-09-15 |
Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis |
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| Cui Hui-Juan,Tong Xiao-Lin,Li Ping,Hao Ying-Xu,Chen Xiao-Guang,Li Ai-Guo,Zhang Zhi-Yuan,Duan Jun,Zhen Min,Zhang Bin,Hua Chuan-Jin,Gong Yue-Wen. Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis[J]. World journal of gastroenterology : WJG, 2004, 10(11): 1652-1655. DOI: 10.3748/wjg.v10.i11.1652 | |
| Authors: | Cui Hui-Juan Tong Xiao-Lin Li Ping Hao Ying-Xu Chen Xiao-Guang Li Ai-Guo Zhang Zhi-Yuan Duan Jun Zhen Min Zhang Bin Hua Chuan-Jin Gong Yue-Wen |
| Affiliation: | 1. Chinese-Japanese Friendship Hospital,Beijing 100029,China 2. Faculty of Pharmacy,University of Manitoba,Canada |
| Abstract: | AIM: To evaluate the hepatic function in patients with severe acute respiratory syndrome (SARS) and possible causes of hepatic disorder in these patients. METHODS: One hundred and eighty-two patients with SARS were employed in a retrospective study that investigated hepatic dysfunction. Liver alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactic dehydrogenase (LDH) were analyzed in these patients. Patients with different hospital treatments were further investigated. RESULTS: Of the 182 patients, 128(70.3%) had abnormal ALT activity, 57(31.3%) had abnormal AST activity and 87(47.8%) had abnormal LDH activity. The peak of elevated hepatic enzyme activities occurred between the sixth day and the tenth day after the first day of reported fever. Of the 182 patients, 160(87.9%) had been treated with antibiotics, 137(75.2%) with Ribavirin, and 115(63.2%) with methylpredisolone. There was no statistically significant correlation between the duration of Ribavirin treatment and hepatic dysfunction. CONCLUSION: Abnormal liver functions were common in patients with SARS and could be associated with virus replication in the liver. |
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