急性非淋巴细胞白血病预后及相关因素分析

为了了解急性非淋巴细胞白血病(ANLL)预后及其影响因素,对1997年1月至2005年1月在我院治疗的94例急性非淋巴细胞白血病进行分析,总结疗效并对影响预后因素进行统计学分析.结果显示完全缓解率51.1%;6、12、18、36、36个月总生存率及无事件生存率分别为68.6%、55.8%、53.8%、46.4%、21.3%及57.9%、38.6%、33.3%、31.6%、0%.经分析年龄＜40岁、化疗前白细胞数＜10.0×109/L、骨髓抑制期白细胞＜1.0×109/L、发病1个月内给予化疗、化疗前输注全血、急性早幼粒细胞白血病患者缓解率及生存率较高;首疗诱导缓解、获得缓解时间、缓解持续时间以及是否复发对生存率有显著影响(p值均＜0.05).结论了解急性非淋巴细胞白血病预后因素,采取个体化治疗并针对各危险因素采取相应治疗,对提高缓解率及生存率具有重要的意义.

Analysis on Prognosis and Correlative Factors of Acute Nonlymphocytic Leukemia

To analyze the prognosis and risk factors of acute nonlymphocytic leukemia (ANLL), 94 patients with acute nonlymphocytic leukemia were enrolled in this study, while survival rate and risk factors of prognosis were analyzed. The results indicated that the complete remission (CR) ratio was 51.1%. Overall survival and event-free survival rates of month 6, 12, 18, 24 were 68.6%, 55.8%, 53.8%, 46.4%, 21.3% and 57.9%, 38.6%, 33.3%, 31.6%, 0% respectively. The factors such as age<40 years, WBC<10.0x10(9)/L before chemotherapy, WBC in the period of bone marrow suppression<1.0x10(9)/L, chemotherapy within 1 month after occurrence of leukemia, blood transfusion before chemotherapy of APL had favourable influence on remission and survival rates of ANLL patients. CR1, the time to get CR, length of CR and relapse significantly correlated with prognosis (p<0.05). It is concluded that the individualized therapy concerning the risk factors should be applied to ANLL patients for improving the remission, survival rate and prognosis.