干细胞移植在急性肾损伤中的应用及研究进展

背景：干细胞移植治疗急性肾损伤是近年来研究的热点,不同来源的干细胞在治疗急性肾损伤方面都取得了很大的进展。目的：对干细胞生物学特性、干细胞的临床研究、不同来源的干细胞治疗急性肾损伤的实验性研究、存在问题及前景进行综述。方法：应用计算机检索中国学术期刊全文数据库(CNKI)和Pubmed 数据库2001-01/2012-02 关于干细胞移植治疗急性肾损伤的文章,检索主题词“干细胞,移植,肾脏疾病,急性肾损伤”或“stem cell,transplantation,kidney disease,acute kidney injury”。初检索到205 篇文献,据纳入标准保留41篇进行分析、综述。结果与结论：干细胞移植是一种尝试用于急性肾损伤治疗的新方法,可以改善肾功能的损伤,加快肾脏修复。虽然仍存在不少有待解决的问题,但干细胞移植仍以其传统方法无法比拟的优势在急性肾损伤领域展现了诱人的应用前景。

Application and research progress of stem cell transplantation in acute kidney injury

BACKGROUND:In recent years, stem cell transplantation has become a “hot spot” problem in the treatment of acute kidney injury. A lot of progress has been achieved regarding different sources of stem cells for treatment of acute kidney injury.OBJECTIVE:To briefly review the experimental study, existing problems and prospective application of stem cells from the aspects of cell biological characteristics, clinical application and different sources of stem cells for treatment of acute kidney injury.METHODS:The CNKI database and Pubmed database (during 2001-01/2012-02) were used to search the related articles about stem cell transplantation in the treatment of acute kidney injury. The retrieval keywords were “stem cell, transplantation, kidney disease, acute kidney injury” in English and Chinese. There were 205 articles by the initial retrieval. Then 41 articles were remained according to the inclusion criteria.RESULTS AND CONCLUSION:Stem cell transplantation is a new method of treatment for acute kidney injury, which can improve renal function and accelerate kidney repair. Although there are many issues to be resolved, and stem cell transplantation still has huge potential advantages compared to the traditional methods, which shows promising applications in the field of acute kidney injury.