组织工程支架材料在脊髓损伤中的应用

背景：近年来，随着基础研究的发展，许多新方法、新策略已经开始用于脊髓损伤修复，其中组织工程学的发展开辟了一条新的途径，利用组织工程学的方法治疗脊髓损伤已逐渐成为当前新的研究热点。目的：探讨组织工程支架材料在脊髓损伤中的应用的研究进展。方法：检索SCI数据库2002/2011有关组织工程支架材料在脊髓损伤中的应用的文献，检索词为“组织工程(tissue engineering)；脊髓损伤(spinal cord injury)；支架材料(scaffold material)；胶原(collagen)；壳聚糖(chitosan)；藻酸盐凝胶(alginate hydrogel)；纤维蛋白凝胶(fibrin glue)；聚羟基丁酸酯(poly-b-hydroxybutyrate)；琼脂糖凝胶(agarose)；聚乳酸(poly lactic acid)；合成水凝胶(synthetic hydrogels)；聚乙二醇(polyethylene glycol)”，对组织工程支架材料修复脊髓损伤的临床及基础文献进行深入分析。结果与结论：组织工程支架是组织工程修复脊髓损伤研究的重点内容。组织工程支架的材料包括天然材料和人工合成材料，天然材料具有良好的细胞和组织相容性，人工合成的聚合物支架在结构形状、机械强度及规模化生产方面均具有很大的优势。近年来,组织工程支架材料在脊髓损伤中的应用有了很大发展，相继出现了新型支架材料。

Tissue engineering scaffold materials in the treament of spinal cord injury

BACKGROUND:In recent years, with the development of basic research, the new method and the new strateg its have been used for repairing spinal cord injury. The development of tissue engineering provides a new approach. The method of tissue engineering to treat spinal cord injury has gradually become a new research hotspot.OBJECTIVE:To explore the progress of tissue engineering scaffolds in treating spinal cord injury.METHODS:A retrieval was performed for the papers regarding tissue engineering scaffolds for spinal cord injury, using key words of “tissue engineering, spinal cord injury, scaffold material, collagen, chitosan, alginate hydrogel, fibrin glue, poly-b-hydroxybutyrate, agarose, poly lactic acid, synthetic hydrogels, polyethylene glycol” in Science Citation Index (SCI) database.RESULTS AND CONCLUSION:Tissue engineering scaffolds play an important role in the tissue engineering to repair spinal cord injury. The tissue engineering scaffold materials include natural materials and synthetic materials. The natural materials have the cell capacity and tissue compatibility, and the synthetic polymer scaffolds have a great advantage in the structure, shape, mechanical strength and large-scale production. In recent years, the tissue engineering scaffold material in spinal cord injury have made a significant progress, and in the novel scaffold materials have appeared.