HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians

Authors:	Asgeir Lande Irene Andersen Torstein Egeland Benedicte A. Lie Marte K. Viken

Affiliation:	1. Department of Medical Genetics, Oslo University Hospital, Oslo, Norway;2. Department of Immunology, Oslo University Hospital, Oslo, Norway;3. Institute of Clinical Medicine, University of Oslo, Oslo, Norway

Abstract:	We report HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 allele frequencies and estimated haplotype frequencies from 4514 healthy Norwegians who volunteered to participate in the Norwegian Bone Marrow Donor Registry. HLA genotyping was conducted on a Next Generation Sequencing platform. Data were analyzed using Arlequin and Pypop software. No significant deviations from Hardy-Weinberg Equilibrium were noted at any of the loci studied. We discuss the representability for the Norwegian population and argue that the presented HLA data could serve as a Norwegian reference panel.

Keywords:	HLA Reference panel Haplotype HLA allele frequency
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