纳洛酮治疗中重度新生儿缺氧缺血性脑病临床观察

目的：观察纳洛酮治疗中重度新生儿缺氧缺血性脑病的临床效果。方法：将100例中重度窒息复苏后的新生儿随机分为治疗组与对照组，对照组在支持综合治疗的基础上使用脑活素或单唾液酸四已糖神经节苷脂钠治疗。治疗组在对照组的基础上加用纳洛酮0．1mg／kg静脉注射，随后改为0．05mg／kg．d静滴持续4h—6h连用3—5天。结果：治疗组总有效率94％，对照组总有效率74％，P〈0．01。结论：纳洛酮治疗中重新生儿缺氧缺血性脑病疗效显著。

Naloxone in the treatment of newborns with hypoxic ischemic encephalopathy

Objective： To observe the re-naloxone treatment of neonatal hypoxic-ischemic encephalopathy clinical effects. Methods： 100 patients with moderate to severe post-resuscitation of neonatal asphyxia were randomly divided into treatment group and control group, the control group in support of comprehensive therapy based on the use of cerebrolysin or single-sugar ganglioside sialic acid sodium treatment had been four. The treatment group in the control group on the basis of 0.1mg/kg intravenous injection of naloxone was added, followed by continuous intravenous infusion into 0.05mg/kg.d used in conjunction 3-5 days, 4h-6h. Results： The total effective rate 94% in the control group, the total efficiency of 74%, P〈0.01. Conclusion： The Luo-one treatment of moderate hypoxic-ischemie encephalopathy remarkable.