Maspin在非小细胞肺癌中的表达及意义

目的：探讨Maspin在非小细胞肺癌（non small cell lung cancer,NSCLC）组织中的表达及临床意义。方法:应用免疫组织化学Picture通用型二步法检测94例NSCLC组织、54例正常支气管黏膜组织、28例肺良性病变中Maspin的表达情况。结果:Maspin在正常支气管黏膜组织及肺良性病变中的阳性表达率分别为100.00%和89.28%，在肺癌组织中的阳性表达率为54.26%，正常支气管黏膜组织与肺癌之间、肺良性病变与肺癌之间的阳性表达率差异有统计学意义（P<0.05），Maspin阳性表达率与NSCLC临床分期、淋巴结转移相关，与病理类型、组织分化程度无关。结论:Maspin在非小细胞肺癌中的表达明显下降，在肺癌发生、发展、转移过程中能发挥调控作用。

Expression of Maspin and its significance in human non-small cell lung cancer

Objective: To study the expression of Maspin in human non-small cell lung cancer.Methods: A immunohistochemical method Picture~(TM) was used to detect maspin in 94 cases of lung cancer,54 of normal bronchial mucosas and 28 of innocent diseases.Results: Maspin expressed itself in 100.00%,89.28%,54.26% of normal bronchial epithelial cell,innocent disease,nonsmall cell lung cancer,respectively(P<0.05).It correlated with LN( )and TNM staging but did not with histological type and classification degree.Conclusion: Maspin significantly decreases in NSCLC,and it may be a sensitive predictor of metastasis and prognosis for NSCLC.