| 灯盏花、丹参液在体外对血小板活化抑制作用的研究 |
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| 引用本文： | 陈辉,邵跃斌,黎庆梅,段朝辉.灯盏花、丹参液在体外对血小板活化抑制作用的研究[J].国际医药卫生导报,2009,15(21):1-5. |
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| 作者姓名： | 陈辉 邵跃斌 黎庆梅 段朝辉 |
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| 作者单位： | 1. 暨南大学第四附属医院/广州市红十字会医院,510220
2. 中山大学孙逸仙纪念医院检验科,广州,510080 |
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| 基金项目： | 广东省中医药局建设中医强省科研课题 |
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| 摘 要： | 目的通过对灯盏花素、丹参在体外对血小板活化抑制作用观察,分析血小板相关活化指标的变化情况,为中医优选活血化瘀药物提供客观理论依据。方法用三色流式细胞术法分析灯盏花素、丹参在体外对血小板活化指标血小板膜表面纤维蛋白原受体（PAC-1）和P-选择素（CD62P）抑制的变化。结果灯盏花素、丹参对ADP活化的血小板膜表面纤维蛋白原受体（PAC-1）和血小板内P-选择素（CD62P）表达都有抑制作用,并且随着药物浓度的增加,抑制作用增强;丹参能显著抑制PAC-1和CD62P两者的表达;灯盏花素抑制PAC-1表达的作用显著,但对CD62P表达的抑制较小。结论与灯盏花素相比,丹参是一种较强的抗血小板活化药物,既可抑制PAC-1的表达而降低血小板的聚集性,又可抑制血小板的释放而降低其促凝血活性,在血栓性疾病的防治中有重要作用。
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| 关 键 词： | 血小板活化 流式细胞术 丹参 灯盏花素 |
Study on the action of breviscapus and saliva for in vitro inhibiting platelet activation |
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| CHEN Hui,SHAO Yao-bing,LI Qing-mei,et al..Study on the action of breviscapus and saliva for in vitro inhibiting platelet activation[J].International Medicine & Health Guidance News,2009,15(21):1-5. |
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| Authors: | CHEN Hui SHAO Yao-bing LI Qing-mei |
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| Institution: | CHEN Hui,SHAO Yao-bing,LI Qing-mei,et al.Department of Laboratory,the fourth Hospital Affiliated to Jinan University,Guangzhou Red Cross Hospital,Guangzhou 510220,China. |
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| Abstract: | Objective To study the action of breviscapus and saliva in inhibiting platelet activation in vitro and to provide more scientific evidence and theoretical basic for the treatment of blood stasis syndrome. Method Two kinds of anti-platelet drugs and controls, which inhibited the expression of fibrinogen receptor (PAC-1) and P-2selectin (CD62P) on activated platelets surface in vitro,were analyzed by tri-color flowcytometry.Results Both of two kinds of anti-platelet drugs can inhibite the expression of PAC-1 ... |
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| Keywords: | Platelet activation Flow cytometry breviscapus Saliva |
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