Alterations in p53, BRCA1, ATM, PIK3CA, and HER2 genes and their effect in modifying clinicopathological characteristics and overall survival of Bulgarian patients with breast cancer |
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| Authors: | Stefan S. Bozhanov Svetla G. Angelova Maria E. Krasteva Tsanko L. Markov Svetlana L. Christova Ivan G. Gavrilov Elena I. Georgieva |
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| Affiliation: | (1) Institute of Genetics “Akad. Doncho Kostoff”, Department of Molecular Genetics, Bulgarian Academy of Sciences, “Plovdivsko shosse” 13 km., 1113 Sofia, Bulgaria;(2) Department of General and Clinical Pathology, Medical University, Sofia, Bulgaria;(3) National Oncological Centre Hospital, Sofia, Bulgaria; |
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| Abstract: | Purpose Though p53, BRCA1, ATM, PIK3CA, and HER2 genes are shown to be involved in various aspects of breast carcinogenesis, their functional relationship and clinical value are still disputable. We investigated the genetic status or expression profile of these genes to further elucidate their clinical significance. |
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