| 曲美他嗪对冠心病心力衰竭患者心脏收缩和舒张功能的影响 |
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| 引用本文： | 刘东,黄晶,邓昌明,高大中,李增高.曲美他嗪对冠心病心力衰竭患者心脏收缩和舒张功能的影响[J].重庆医科大学学报,2003,28(6):804-806. |
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| 作者姓名： | 刘东 黄晶 邓昌明 高大中 李增高 |
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| 作者单位： | 重庆医科大学第二临床学院心内科,重庆,400010 |
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| 摘 要： | 目的 :探讨曲美他嗪对冠心病慢性心力衰竭患者心脏收缩和舒张功能的影响。方法 :观察冠心病慢性心力衰竭患者4 5例 ,其中曲美他嗪组 2 3例 ,对照组 2 2例。分别测定用药前及用药 6月后两组患者的超声心动图心功能指标SV ,CO ,CIandLVEF ,VA ,VE ,VA/VE。结果 :用药 6月后曲美他嗪组患者的SV ,CO ,CI及LVEF较对照组显著增高 (P <0 .0 5 ) ,但VA ,VE及VA/VE与对照组相比无显著性差异 (P >0 .0 5 )。结论 :曲美他嗪通过改善缺血心肌细胞的能量代谢 ,可保护缺血心肌细胞的功能 ,从而改善心脏的收缩功能。
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| 关 键 词： | 曲美他嗪 冠心病 心力衰竭 心功能 |
| 文章编号： | 0253-3626(2003)06-0804-03 |
| 修稿时间： | 2002年9月17日 |
Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease |
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| LIU Dong,et al.Effect of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease[J].Journal of Chongqing Medical University,2003,28(6):804-806. |
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| Authors: | LIU Dong |
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| Abstract: | Objective:To investigate the effects of trimetazidine on cardiac systolic and diastolic function in patients with chronic congestive heart failure due to coronary artery disease.Methods:45 patients with chronic congestive heart failure due to coronary artery disease were divided into two groups,23 patients in trimetazidine group and 22 in placebo-control group.The echocardiogram indices of cardiac function of patients in two groups-SV,CO,CI,LVEF,VA,VE and VA/VE were measured before and after treatment.Results:The indexes SV,CO,CI and LVEF were significantly higher in trimetazidine group than those in control group(P<0.05),but no significant difference in VA,VE and VA/VE was observed between the two groups(P>0.05).Conclusion:Trimetazidine can improve systolic function of ischemic heart by improving the energy metabolism of ischemic heart. |
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| Keywords: | Trimetazidine Coronary artery disease Heart failure Cardiac function |
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