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| 异烟肼控释片剂的研制 | |
| 引用本文： | 孙殿甲,崔玉琴. 异烟肼控释片剂的研制[J]. 新疆医科大学学报, 1989, 12(3): 171-173 |
| 作者姓名： | 孙殿甲 崔玉琴 |
| 作者单位： | 新疆医学院药学系药剂学教研室，新疆医学院药学系药剂学教研室，新疆医学院药学系药剂学教研室，新疆医学院药学系药剂学教研室，新疆医学院药学系药剂学教研室 |
| 摘 要： | 本文研究了异烟肼控释片剂的处方组成、制备工艺、体外溶出度及在兔体内的血药浓度。数据按单室模型进行处理,求得动力学参数。结果表明:控释片剂1h达有效血药浓度,浓度维持在5～15μg/m1以上达24h。控释片体内外具有相关性,因此溶出度可作为控制控释片剂的质量标准。 |
| 关 键 词： | 异烟肼 控释片剂 溶出度 药物动力学参数 |
Studies on Controlled Release Isoniazid Tablets |
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| Sun Dianjia,et al. Studies on Controlled Release Isoniazid Tablets[J]. Journal of Xinjiang Medical University, 1989, 12(3): 171-173 | |
| Authors: | Sun Dianjia et al |
| Affiliation: | Sun Dianjia,et al Department of Pharmacy,Xinjiang Medical College |
| Abstract: | The formulation, preparation process, dissolution rate and plasma le-vel in rabbit of controlled release isoniazid tablets were studied. The phar-macokinetic parameters were fitted in the basis of one compartment model.The therapeutic plasma level of controlled-release isoniazid tablets was att ained at lh and then maintained over 5-15ug/ml for up to 24h. The corre lation between dissolution rate and plasma levels was good. Then the dis solution rate referred to controlling controlled-release isoniazid tablets as quality standard. |
| Keywords: | controlled release isoniazid tablets dissolution rate pharmacokinetic parameter |
| 本文献已被 CNKI 维普 等数据库收录！ | |