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In vivo assessment of experimental neonatal excitotoxic brain lesion with USPIO-enhanced MR imaging |
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| Authors: | Marianne Alison Robin Azoulay François Chalard Pierre Gressens Guy Sebag |
| Affiliation: | 1. INSERM U676,H?pital Robert Debré, AP-HP, 48 Bd Sérurier, 75019, Paris, France 2. Faculté de Médecine Denis Diderot, IFR02 and IFR25, Université Paris 7, Paris, France 3. Service d’Imagerie Pédiatrique, H?pital Robert Debré, AP-HP, 48 Bd Sérurier, 75019, Paris, France 4. Service de Neurologie Pédiatrique, H?pital Robert Debré, AP-HP, Paris, France 5. PremUP, Paris, France |
| Abstract: | Purpose:To assess the feasibility of magnetic resonance imaging (MRI) enhanced with ultrasmall superparamagnetic particles of iron oxide (USPIO) for assessing excitotoxic brain lesions in an experimental model of neonatal periventricular white matter (PWM) lesions.Materials and methods:Brain lesions were induced by intracerebral injection of ibotenate in 14 newborn rats. Pre- and post-USPIO T2-weighted MRI was performed in seven of them (group A) and in five control newborns (group C). In seven newborns with induced cerebral lesions, USPIO-enhanced MRI was not performed (group B). We compared the signal intensity of the lesion to the contralateral unaffected brain (lesion-to-brain contrast, LBC) and the lesion signal-to-noise ratio (SNR) before and after USPIO injection. MR imaging was correlated with histology.Results:USPIO injection significantly (P?P?Conclusion: Post-USPIO T2-weighted MRI demonstrated negative enhancement of neonatal excitotoxic brain lesion. USPIO injection does not appear to exacerbate brain lesions. |
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