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| 杭白菊对衰老小鼠肝组织SOD、GSH-PX和MDA表达的影响 | |
| 引用本文： | 于亚威,徐广涛,潘晓燕,周新妹,沈岳良.杭白菊对衰老小鼠肝组织SOD、GSH-PX和MDA表达的影响[J].温州医学院学报,2011,41(1):53-55. |
| 作者姓名： | 于亚威 徐广涛 潘晓燕 周新妹 沈岳良 |
| 作者单位： | 1. 嘉兴市第二医院,病理科,浙江,嘉兴,314001 2. 嘉兴学院医学院,病理学教研室,浙江,嘉兴,314001 3. 浙江大学医学院,生理学教研室,浙江,杭州,310058 |
| 基金项目： | 浙江省科技计划资助项目，嘉兴市科技计划资助项目 |
| 摘 要： | 目的：研究杭白菊对衰老模型小鼠肝组织超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）和丙二醛（MDA）表达的影响,探讨其对肝组织的保护作用。方法：以D-半乳糖建立人工致衰老小鼠并给予杭白菊灌胃处理,ICR雌性小鼠64只,每组16只,随机分成4组,空白对照组、D-半乳糖对照组、维生素E处理组和杭白菊处理组,检测小鼠血清和肝组织中SOD、GSH-PX活性及MDA的含量。结果：杭白菊处理组血清、肝中SOD、GSH-PX含量均高于D-半乳糖对照组（P〈0.01）,血清MDA低于D-半乳糖对照组（P〈0.01）。杭白菊处理组血清、肝中SOD、GSH-PX、血清MDA含量与维生素E处理组及空白对照组差异无统计学意义（P〉0.05）。结论：杭白菊主要通过提高抗氧化酶活性,清除或减少氧自由基和脂质过氧化物而实现其保护肝组织的作用。 |
| 关 键 词： | 杭白菊 D-半乳糖 肝脏 小鼠 衰老 |
Effects of Chrysanthemum morifolium on expression of SOD, GSH-PH and MDA of liver tissue in D-gal-induced aging mice model |
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| YU Yawei,XU Guangtao,PAN Xiaoyan,ZHOU Xinmei,SHEN Yueliang.Effects of Chrysanthemum morifolium on expression of SOD, GSH-PH and MDA of liver tissue in D-gal-induced aging mice model[J].Journal of Wenzhou Medical College,2011,41(1):53-55. | |
| Authors: | YU Yawei XU Guangtao PAN Xiaoyan ZHOU Xinmei SHEN Yueliang |
| Institution: | YU Yawei,XU Guangtao,PAN Xiaoyan,ZHOU Xinmei,SHEN Yueliang.Department of Pathology,the Second Hospital of Jiaxing,Jiaxing,314001 |
| Abstract: | Objective: To investigate the protective effects of dendranthema morifolium(DM)on liver tissue and expression of SOD,GSH-PX and MDA of liver tissue in D-gal-induced aging mice model.Methods: Sixty-four ICR female mice were randomly divided into control group,D-galactose control group,Vit-E treatment group and the dendranthema morifolium(DM)treatment group,16 rats in each.The aging mice model was established by D-galactose and dealt with DM to measure the content of SOD,GSH-PX and MDA in liver and serum.Resu... |
| Keywords: | dendranthema morifolium D-galactose liver mice aging |
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