冠心病血清可溶性粘附分子水平与血脂异常的关系

目的 :通过检测冠心病 (CHD)患者血清可溶性细胞间粘附分子 - 1(sICAM - 1)、血管细胞间粘附分子 - 1(sVCAM -1)和E -选择素 (sE -selectin)水平 ,分析血脂水平与可溶性粘附分子水平 (CAMs)的相关性 ,以期探讨血脂异常对CAMs表达的影响。方法 :用ELISA法检测了 6 0例经冠脉造影诊断的CHD患者血清slCAM - 1、sVCAM -l、sE -selectin水平 ,并以 18例健康体检者作为对照。结果 :与对照组比较 ,sICAM - 1水平于稳定性心绞痛 (SAP)组增高 ,有显著性意义 (P<0 0 5 ) ,于不稳定性心绞痛 (UAP)组、急性心肌梗塞 (AMl)组增高更为显著 (P 0 0 5 )。在CHD组内 ,血脂异常组与血脂正常组相比 ,sICAM - 1水平于血脂异常组增高 ,有显著性意义 (P

Alterations in the Levels of Soluble Cell Adhesion Molecules in Patients With Coronary Heart Disease and Their Relationship With Dyslipidemia

Objetives: To explore the relationship of soluble cell adhesion molecules with dyslipidemia in coronary heart disease Methods:By using ELISA method,the levels of sICAM-1,sVCAM-1 and sE-selectin in serum were measured for 60 patients with coronary heart disease diagnosed by coronary arteriography and for 18 healthy persons as controls Results: The level of slCAM-1 with CHD was significantly higher than that of controls,especialy in UAP and AMI groups(P<0 01) The UAP and AMI group had higher level of sVCAM-1 and sE-selectin than that in control group(P<0 01) CHD patients with dyslipidemia had higher level of slCAM-1(P<0 01) and sVCAM-1(P<0 05)than those patients with normal lipid Multivariable analysis showed that TC and LDL-C were independently associated with sVCAM-1 while LDL-C and HDL-C were independent factors affecting the levels of slCAM-1 and sE-selectin Conclusions:The level of soluble CAMs was elevated in patients with CHD and dyslipidemia affected the level of soluble CAMs