| 氯胺酮灌胃,滴鼻对动物的作用 |
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| 引用本文： | 戴体俊,傅英.氯胺酮灌胃,滴鼻对动物的作用[J].临床麻醉学杂志,1997,13(4):196-197. |
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| 作者姓名： | 戴体俊 傅英 |
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| 作者单位： | 徐州医学院麻醉药理学教研室 |
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| 基金项目： | 江苏省教委自然科学基金 |
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| 摘 要： | 观察用市售胺酮注射剂给动物灌胃，滴鼻的作用并与静注比较，测得氯胺酮灌胃引起翻正反射消失的ＥＤ５０和ＬＤ５０分别为５２．８ｍｇ／ｋｇ和５７３．２ｍｇ／ｋｇ分别为静注的３．８和７．６倍，氯胺酮１７２．２４５和３５０ｍｇ／ｋｇ灌胃，小鼠平均睡眠时间分别为５９．１，１３０．７和２５４．５ｍｉｎ，呈明显剂量依赖关系，但３个剂量组入睡潜伏期相似，兔每侧鼻孔分别滴入０．１，０．２和０．３ｍｌ氯胺酮，均引起家兔翻
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| 关 键 词： | 氯胺酮 术前用药 麻醉药 灌胃 滴鼻 药理学 |
The Effect of Intragastric or Intranasal Ketamine in Animals |
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| Dai Tijun,Fu Ying.The Effect of Intragastric or Intranasal Ketamine in Animals[J].The Journal of Clinical Anesthesiology,1997,13(4):196-197. |
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| Authors: | Dai Tijun Fu Ying |
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| Institution: | Dai Tijun,Fu Ying Department of Anesthetic Pharmacology,Xuzhou Medical College |
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| Abstract: | The effect of intragastric or intranasal ketamine for premedication was studied in animals.The hypnotic ED 50 and LD 50 of ketamine administered intragastircally in mice were 52 8 and 573 2 mg/kg respectively,which were 3 7 and 7 6 times of that given iv.Ketamine 172,245 or 350 mg/kg intragastrically induced a dose dependent loss of righting reflex for 59 1,130 7 and 254 5 min respectively.Intranasal administration of ketamine 0 1,0 2 or 0 3 ml induced loss of righting reflex in all rabbits studied. |
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| Keywords: | Ketamine Premedication |
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